Phase 2 Head and Neck Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with HPV-associated squamous cell carcinoma (a type of cancer linked to the HPV virus) of the oropharynx — which includes the tonsils, base of the tongue, or the walls of the throat — confirmed by a tissue or cell sample from a biopsy or surgery.
• People with squamous cell carcinoma found in a neck lymph node where the original source of the cancer is unknown, provided a suitable biopsy has been performed (confirm with trial site).
• People who have visible or measurable cancer present at the throat area or in the lymph nodes of the neck.
• People whose cancer is at a certain stage and spread level as defined by medical staging guidelines (AJCC 7th Edition: T3-4/N0-2c or any N3), or who have cancer spread to neck lymph nodes from an unknown primary site, with no sign of cancer having spread to distant parts of the body (confirmed by a PET/CT scan).
• People who have had a CT scan or MRI of the neck as part of their assessment.
• People who are generally able to carry out daily activities, rated as ECOG 0–2 or a Karnofsky score of 70 or above (a measure of physical ability and daily function).
• People aged 18 or older.
• People whose blood test results within the past 30 days show that their blood cell counts and bone marrow function are within acceptable ranges for the trial.
• People whose kidney function test results within the past 30 days are within acceptable ranges for the trial.
• People whose liver function test results within the past 30 days are within acceptable ranges for the trial.
• Women who could potentially become pregnant must have a negative pregnancy blood test within 14 days before joining.
• People who have received one cycle of initial (induction) chemotherapy before joining, if medically needed.
• People who are willing and able to provide written consent to participate in the study.
• People who are able to have MRI scans, or who have been approved by the lead investigators to participate without MRI scans due to a valid medical reason (such as having a pacemaker).

Who may not be able to join:

• People who have previously received radiation therapy to the head or neck area.
• People who have another active cancer occurring at the same time in a different part of the body, unless the lead investigators determine it is safe to proceed (confirm with trial site).
• People who have had a previous cancer (other than certain non-serious skin cancers) unless they have been cancer-free for at least 3 years, or their previous cancer had a very high chance of being cured (90% or greater at 5 years).
• People who have already received chemotherapy specifically for the cancer being studied in this trial (chemotherapy for a different, unrelated cancer is generally acceptable).
• People with serious, active health conditions, including:
  • Unstable chest pain or heart failure that required a hospital stay in the past 6 months.
  • A severe heart attack within the past 6 months.
  • A current serious bacterial or fungal infection that requires intravenous antibiotics.
  • A severe flare-up of a chronic lung condition, or another breathing problem that required hospitalisation or would prevent participation in the trial, within the past 30 days.
  • Severe liver disease causing visible yellowing of the skin or eyes, or problems with blood clotting.

Important: Always verify eligibility with the trial site directly before applying.