Phase 3 Parkinson's Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are 18 years of age or older at the time of screening (other age rules may also apply depending on local regulations)
• People who have been diagnosed with a specific type of uterine (endometrial) cancer confirmed by a tissue sample — all subtypes are allowed except sarcomas, though carcinosarcomas are allowed
• People who have advanced endometrial cancer (Stage III or IV) or cancer that has come back for the first time after surgery or a biopsy, meeting specific staging conditions (confirm with trial site)
• People whose cancer tests positive for a protein called HER2 at a level of 3+ or 2+, confirmed by central laboratory testing arranged by the trial
• People whose cancer tests positive for a feature called pMMR (meaning certain DNA repair proteins are working normally), confirmed by central laboratory testing
• People who can provide a suitable tumour tissue sample from a lesion that has not been treated with radiation, for central laboratory testing
• People who have not yet received treatment for advanced or recurrent disease, though one prior course of chemotherapy or chemoradiation given with the intention of cure is allowed — provided the cancer came back or progressed at least 6 months after the last chemotherapy dose; prior use of a drug called trastuzumab in that earlier setting is also allowed
• People who have never received certain types of cancer treatments called ADCs (antibody-drug conjugates), immune checkpoint inhibitors, or therapeutic cancer vaccines
• People who may have had prior radiation therapy for endometrial cancer (including pelvic, extended field, or internal radiation), provided enough time has passed since treatment
• People with a general health and activity level rated 0 or 1 on a standard oncology scale, meaning they are fully active or have only minor restrictions on physical activity (confirm with trial site)
• People whose heart pumping function (left ventricular ejection fraction) is at least 50%, measured within 28 days before joining the trial
• People whose organ function and blood counts meet required levels, tested within 14 days before joining the trial

Who may not be able to join:

• People who have had an organ transplant at any point
• People with ongoing or poorly controlled illness, including active infections, serious long-term gut conditions involving diarrhoea, or active non-infectious skin disease that requires systemic (whole-body) treatment
• People with spinal cord compression or active cancer spread to the brain or central nervous system
• People who have had a heart attack within the 6 months before joining, or who have significant heart failure, clinically important irregular heartbeat, or any form of heart muscle disease; people with elevated troponin levels (a heart marker) at screening will need a cardiology review before enrolment
• People with a history of lung inflammation (ILD/pneumonitis) that was not caused by infection and required steroid treatment, or who currently have or are suspected to have this condition
• People with certain lung-related conditions, including blood clots in the lungs within the past 3 months, severe asthma, severe chronic obstructive pulmonary disease (COPD), restrictive lung disease, or significant fluid around the lungs
• People with autoimmune, connective tissue, or inflammatory conditions where lung involvement is confirmed or suspected
• People who have had a complete surgical removal of one lung
• People with active or previously documented autoimmune or inflammatory conditions that have required ongoing treatment with steroids or other immune-suppressing medications
• People with active immune system deficiencies or certain active infections, including tuberculosis, poorly controlled HIV, or active or chronic hepatitis B or C (though people with chronic hepatitis B who are on antiviral treatment with normal liver function and controlled viral levels may be considered)
• People who are currently receiving other cancer treatments without having had an adequate break beforehand (hormone therapy for non-cancer reasons, such as hormone replacement therapy, is allowed)

Important: Always verify eligibility with the trial site directly before applying.