Phase 1 Lung Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 or older, of any gender.
• People who have been diagnosed with advanced, spreading, or returning lung cancer (either non-small cell lung cancer or small cell lung cancer), confirmed through a tissue or cell sample.
• People whose cancer has continued to grow or who could not tolerate standard treatments — for non-small cell lung cancer, this means after at least two rounds of standard treatment; for small cell lung cancer, after at least one round of standard treatment.
• People assigned to the fluid-drainage group who have fluid buildup around the lungs that has been confirmed by scans and lab tests to contain cancer cells.
• People whose tumour has tested positive for a protein called CEA (by a lab test on a tissue sample within the last 3 months, or by a blood test showing CEA above 10 µg/L if the tissue test was done more than 3 months ago).
• People who have at least one tumour area that can be measured on a scan, meeting specific size requirements set by the trial.
• People with a general health and activity level rated 0, 1, or 2 on a standard medical scale (meaning able to carry out at least some daily activities).
• People whose life expectancy is estimated to be more than 12 weeks.
• People who do not have a severe psychiatric (mental health) disorder.
• People whose blood counts, heart, kidneys, liver, and oxygen levels all meet the minimum thresholds set by the trial (confirm specific values with the trial site).
• People who are able to have a blood cell collection procedure, with no medical reasons preventing it.
• People who are willing to use reliable contraception from the time of signing consent until one year after receiving the cell treatment (the rhythm method is not considered acceptable under this criterion).
• People (or their legal representative) who have read and voluntarily signed the consent form, showing they understand and agree to take part.

Who may not be able to join:

• People who have active, uncontrolled cancer spread to the brain or the lining around the brain at the time of screening.
• People who have taken part in another clinical trial within the past month before screening.
• People who have received a live vaccine within the 4 weeks before screening.
• People who have received chemotherapy, targeted therapy, or any experimental cancer treatment within a recent short window before screening (confirm exact timeframes with the trial site).
• People who have an active infection that requires treatment, or any infection that is not under control.
• People whose tumour is pressing on the windpipe or major blood vessels in a way the doctor considers high risk.
• People with a history of serious heart conditions, including severe heart failure, a heart attack or certain heart surgery within the past 6 months, significant irregular heart rhythms, unexplained fainting episodes, or severe heart muscle disease.
• People who have an active autoimmune disease or who need long-term medication to suppress their immune system.
• People who have had another untreated cancer within the past 3 years, except for certain very early-stage skin or cervical conditions.
• People who test positive for hepatitis B, hepatitis C, HIV, or syphilis under the specific conditions outlined by the trial (confirm details with the trial site).
• People who are pregnant or breastfeeding.
• People whom the trial doctor considers unsuitable for any other reason.

Important: Always verify eligibility with the trial site directly before applying.