Phase 2 Head and Neck Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older
• People whose general health and ability to function day-to-day is rated at a certain level (a score of 2 or less on a standard oncology scale, where lower scores mean fewer limitations — confirm with trial site)
• People who have been diagnosed with a type of cancer called squamous cell carcinoma in the head and neck area, including cases where the cancer has spread to neck lymph nodes but the original source is unknown, confirmed by a tissue biopsy
• People whose cancer is being treated with the goal of curing it, using a combination of chemotherapy and radiation therapy
• People whose treating cancer doctor has determined them suitable to receive chemotherapy, preferably a platinum-based type, alongside radiation
• People who are able to swallow and keep down oral medication
• People of childbearing potential who agree to use adequate contraception throughout the study, and who agree to notify their treating doctor immediately if pregnancy occurs or is suspected during the study period
• People who agree to avoid the combination medication Symbyax (which already contains one of the study drugs), avoid alcohol, and avoid operating vehicles or hazardous machinery until it is reasonably established that the study drug does not affect mental or physical function
• People who understand the experimental nature of the study and have signed an approved written consent form before any study procedures begin

Who may not be able to join:

• People whose radiation therapy is planned for comfort or symptom relief only, rather than with a curative goal
• People who already have a feeding tube
• People who regularly take steroid medications
• People who are currently using atypical antipsychotic medications (note: certain other anti-nausea medications that work on dopamine receptors, such as prochlorperazine or metoclopramide, are permitted)
• People with serious uncontrolled health conditions, including active infections, certain heart conditions, uncontrolled diabetes, or mental health or personal circumstances that may make it difficult to follow the study requirements
• People with a known allergy or sensitivity to olanzapine (one of the study drugs)
• People who are pregnant or currently breastfeeding
• People with a known history of seizures
• People who are unwilling or unable to follow the study's requirements
• People whom the trial investigators consider unsuitable for the study drug for any other reason

Important: Always verify eligibility with the trial site directly before applying.