Phase 2 Endometrial Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are able to understand and voluntarily agree to participate by signing a consent form before any study procedures begin.
• Female participants aged 18 or older at the time of signing the consent form.
• People whose general physical functioning is rated as 0 or 1 on a standard cancer performance scale (meaning fully active or able to carry out light work).
• People with an expected survival of at least 6 months.
• People whose cervical cancer has been confirmed through laboratory analysis of tissue or cell samples.
• People who have at least one measurable tumour that meets specific size criteria used in cancer research.
• People who are willing to provide a tumour tissue sample before joining the trial.
• People whose recent blood test results (taken within 7 days before joining) show that the blood, liver, and kidneys are functioning within acceptable ranges for this trial (confirm with trial site for exact values).
• Women who could potentially become pregnant must have a negative pregnancy blood test within 72 hours before treatment starts, and must use two forms of contraception from the screening period through at least 120 days after the last trial dose, or at least 180 days after completing chemoradiation.

Who may not be able to join:

• People whose cervical cancer is of certain less common types, such as neuroendocrine carcinoma, small cell carcinoma, or sarcoma.
• People whose tumour is a mixed type with more than 50% of a non-squamous component.
• People who have had their entire uterus and cervix surgically removed (total hysterectomy); partial removal that preserves the cervix may still be permitted (confirm with trial site).
• People whose anatomy or tumour shape makes a specific type of internal radiation treatment (brachytherapy) impossible to use.
• People with a significant blockage of both kidneys that cannot be relieved by medical procedures, as assessed by the treating doctor.
• People who have had another active cancer in the past 2 years, except for certain types that have been fully treated and cured, such as some skin cancers, superficial bladder cancer, or non-invasive breast cancer.
• People who have previously received immune checkpoint inhibitor therapy or other immunotherapy treatments that target immune system stimulatory pathways.
• People who have used high-dose steroid medications or other immune-altering drugs within 2 weeks before joining.
• People who have received a live vaccine within 4 weeks before joining.
• People who have had major surgery, an open biopsy, or serious physical trauma within 4 weeks before joining, or who have major surgery planned during the trial period.
• People with active infections requiring ongoing treatment, or active autoimmune diseases (some exceptions apply — confirm with trial site).
• People with a known immune deficiency condition, including those who test positive for HIV.
• People with a history of or currently active inflammatory bowel disease (such as Crohn's disease or ulcerative colitis) or active diverticulitis.
• People who have had an organ transplant or bone marrow/stem cell transplant from another person.
• People with a known history of lung inflammation (interstitial lung disease) or non-infectious pneumonia.
• People with a known history of severe allergic reactions to monoclonal antibody medications.
• People who have had a heart attack, unstable chest pain, blood clots in the lungs, aortic dissection, deep vein clots, or a stroke within 6 months before joining.
• People with moderate to severe heart failure.
• People with serious heart rhythm problems requiring long-term medication.
• People with a weakened heart pumping function below a specific threshold (confirm with trial site).
• People with a history of heart muscle inflammation or disease (myocarditis or cardiomyopathy).

Important: Always verify eligibility with the trial site directly before applying.