Lung Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with a type of lung cancer called non-small cell lung cancer (NSCLC) — specifically adenocarcinoma, squamous cell carcinoma, or large cell carcinoma — confirmed by a tissue biopsy or pathology test.
• A special type of scan called a PET-CT has shown that your lung cancer has spread to lymph nodes on the opposite side of your chest from the main tumour (known as N3 stage).
• You are between 18 and 75 years old.
• Your heart and lungs are working well enough to safely undergo surgery, including having a heart pumping function (LVEF) of at least 45% and a breathing test result (FEV1) of at least 50% of the expected value for someone your age and size.
• Doctors have reviewed your scans and determined that your tumour can be surgically removed, along with lymph nodes on both sides of your chest.
• Scans of your whole body show no signs that the cancer has spread to other parts of the body (no distant metastasis).
• You are generally in good physical health and able to carry out your normal daily activities independently (this is measured by a scoring system called ECOG, with a score of 0 or 1).
• You and your family are willing to sign a consent form after being fully informed about the study, including its purpose, risks, and potential benefits.

Who may not be able to join:

• Your tumour cannot be fully removed by surgery, for example because it has grown into major blood vessels, the spine, or the heart.
• You have serious heart or lung conditions, such as heart failure, a previous heart attack, irregular heartbeat, severe asthma, or other uncontrolled long-term illnesses that make surgery unsafe.
• Your scans show that the cancer has already spread to other organs, such as the liver, bones, or brain.
• You have a known severe allergy to anaesthetic drugs, or your heart or lung health makes anaesthesia too risky.
• You are currently pregnant or breastfeeding.
• You have a psychiatric condition or are otherwise unable to fully understand and agree to the study's consent process independently.
• You are unable to attend follow-up appointments after surgery, for example due to living too far from the hospital or other practical barriers.
• You have another type of cancer in addition to lung cancer, particularly one with a high risk of coming back.
• You have a known immune system disorder or severe immunodeficiency, including HIV, or you have had an organ transplant.
• You are an older adult with multiple chronic health problems or declining physical function that makes surgery or anaesthesia too risky (confirm with trial site).
• You have severe liver disease (such as cirrhosis) or kidney failure that could prevent you from safely having surgery or recovering from it.
• You currently have an active infection, such as pneumonia, tuberculosis, or bacterial infection being treated with antibiotics.
• You have diabetes with poorly controlled blood sugar or serious diabetes-related complications, such as problems with your feet or eyesight.
• You are currently taking part in another clinical trial that could interfere with this study's treatments.
• You are significantly malnourished or have experienced serious unintended weight loss that could affect your recovery from surgery.
• You have a serious blood disorder, such as very low red blood cell counts (anaemia) or low platelet counts, which could cause problems with bleeding during or after surgery.
• You are dependent on a ventilator or have had a tracheostomy (a surgical opening in the throat for breathing) due to severe long-term breathing failure.

Important: Always verify eligibility with the trial site directly before applying.