Phase 3 Lung Cancer Trial, Recruiting NCT07005128 Sponsor: Amgen Condition: Lung Cancer
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Phase 3 Lung Cancer Trial, Recruiting

NCT07005128
Recruiting Phase 3 🇦🇺 Australian site

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • People who have given their written agreement to participate before any trial-related activities begin
  • People aged 18 or older (or the legal adult age in their country, if that is older than 18)
  • People who have been diagnosed with an advanced (extensive-stage) form of small cell lung cancer, confirmed through a tissue or cell sample, meeting specific staging criteria as defined by medical guidelines
  • People whose cancer can be measured on scans, according to standard measurement guidelines called RECIST 1.1
  • People whose doctor determines they are suitable to receive a treatment combination of carboplatin, etoposide, and durvalumab as their first treatment for this cancer
  • People with a life expectancy of at least 12 weeks

Who may not be able to join:

  • People who have had another type of cancer in the past 2 years
  • People who have cancer that has spread to the brain or spinal cord and is causing symptoms, or who have cancer spreading along the lining of the brain or spinal cord
  • People who have previously had a severe or life-threatening reaction to an immune-based therapy
  • People who have had a blood clot in an artery — such as a stroke or mini-stroke — within the 6 months before the start of the trial treatment
  • People who have an active autoimmune or inflammatory condition
  • People with an active HIV infection or active Hepatitis B or C infection
  • People who have a lung condition called interstitial lung disease, or current non-infectious inflammation of the lungs
  • People who have had an organ transplant
  • People who have had a heart attack or significant heart failure within the 6 months before the start of the trial treatment

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 16 July 2026
Phase 3: approximately ~65% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Principal Investigator: MD, Amgen

Phone: 866-572-6436

Australian sites

Chris OBrien Lifehouse, Camperdown, New South Wales
Monash Medical Centre, Clayton, Victoria

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 3
Sponsor
Registry
ClinicalTrials.gov
Start date
18 August 2025
Est. completion
4 January 2029

Where this trial is recruiting

🇦🇷 Argentina 🇦🇺 Australia 🇦🇹 Austria 🇧🇪 Belgium 🇧🇷 Brazil 🇨🇳 China 🇩🇰 Denmark 🇫🇷 France 🇩🇪 Germany 🇬🇷 Greece Hong Kong 🇭🇺 Hungary 🇮🇱 Israel 🇮🇹 Italy 🇯🇵 Japan 🇲🇽 Mexico 🇳🇱 Netherlands 🇵🇱 Poland 🇵🇹 Portugal 🇷🇴 Romania 🇰🇷 South Korea 🇪🇸 Spain 🇨🇭 Switzerland 🇹🇼 Taiwan Turkey (Türkiye) 🇺🇸 United States

2 site(s) in Australia. Confirm current status and contact details directly with the trial site.

Primary endpoints

Overall Survival (OS); Progression free survival (PFS) (Blinded Independent Central Review [BICR] Assessed)

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 16 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov