Migraine Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged between 18 and 75 years (male or female)
• People with a confirmed migraine diagnosis (with or without aura) based on recognised international headache guidelines, meaning they have had at least 5 migraine attacks that last between 4 and 72 hours, with specific features such as one-sided head pain, throbbing sensation, moderate-to-severe pain, or pain that gets worse with normal movement, and that are accompanied by nausea, vomiting, or sensitivity to light and sound
• People who experience at least 6 migraine headache days per month over the past 3 months
• People with a stable body weight, with a BMI (body mass index) between 18.5 and 35.0
• People whose migraine medications (both preventive and pain-relief) have not changed significantly in the past 3 months, and who are willing to keep them stable or reduce them if not needed during the study
• People who are willing and able to complete a daily electronic diary using a mobile app or website, and follow the study instructions
• People who have signed a consent form agreeing to take part

Who may not be able to join:

• People who have other types of primary headache conditions, such as tension-type headache, cluster headache, or fibromyalgia
• People whose headaches are caused by another condition such as a head injury, trauma, or infection
• People who use pain-relief headache medication too frequently (more than 10–15 days per month, depending on the medication — the trial doctor decides this)
• People with serious medical conditions that affect how the body absorbs or processes substances, including long-term use of laxatives
• People who have had weight-loss (bariatric) surgery
• People with serious mental health conditions, such as severe depression or significant cognitive difficulties, that could affect their ability to complete the diary or be assessed during the study (the trial doctor decides this)
• People currently taking other dietary supplements that could potentially affect migraines, unless willing to stop taking them at least 3 months before the study begins
• Women who are pregnant, breastfeeding, or planning to become pregnant during the study
• Women of childbearing potential who are not using a medically recognised form of contraception, unless they have had a tubal ligation or their male partner has had a vasectomy
• People with known allergies or intolerances to any ingredients in the study product
• People who have recently had Botox injections for migraine (within the last 6 months, unless it is an already established ongoing treatment), nerve blocks, or other invasive migraine treatments in the last 6 months
• People currently taking part in another clinical trial, or who have participated in one in the last 3 months
• People with difficulty swallowing
• People with a history of chronic drug or alcohol misuse
• People taking blood-thinning medication containing coumarin compounds (a type of anticoagulant)
• People with liver or bile duct disorders
• People with an active cancer diagnosis or currently receiving immune-suppressing therapy
• People with an underactive thyroid (hypothyroidism)
• People who work closely with the research team, the study sponsor, or the study coordinator
• People who are under legal guardianship or court-ordered protection (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.