Phase 2 Bladder Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older who have given written consent to participate
• People who have been diagnosed with a specific low-grade, early-stage bladder cancer (called TaLG bladder cancer), either as a first-time diagnosis or as a return of a previously treated cancer, confirmed by a tissue sample taken at or within 8 weeks before the screening visit
• People whose largest bladder tumor measures 15mm or less in diameter, as seen on a bladder camera examination (cystoscopy)
• People with no more than 5 bladder tumors present
• People who have had a bladder camera examination with a detailed diagram recording the number, location, size, and appearance of tumors, including photos
• People whose cancer has returned but remains only low- or intermediate-risk early-stage bladder cancer, with no other cancer types present
• People whose condition requires a surgical procedure to remove bladder tumors (called TURBT)
• People whose urine cell test (cytology) showed no sign of high-grade disease within 8 weeks before the screening visit
• People with no cancer spread to lymph nodes or other parts of the body
• People who are willing and able to use effective contraception throughout the study and for at least 6 months after treatment ends
• Women who could become pregnant must have a negative blood pregnancy test within 2 weeks before enrolling, and must use adequate contraception throughout the study
• People who are willing and able to give informed consent

Who may not be able to join:

• People whose tumors are suspected by their doctor to be high-grade (more aggressive) cancer
• People whose urine cell test showed high-grade cancer cells, based on recognised testing standards
• People whose largest tumor is greater than 15mm in diameter
• People with more than 5 bladder tumors
• People who have had any treatment placed directly into the bladder within the past year
• People who have had high-grade early-stage bladder cancer within the last 3 years (a history of high-grade disease more than 3 years ago may still be considered — confirm with trial site)
• People who have had, or currently have, bladder cancer that has grown into the bladder muscle or spread to other parts of the body
• People with a history of cancer in the upper urinary tract (the kidneys or tubes leading to the bladder)
• People with a significant narrowing of the urethra that would prevent a catheter from being inserted
• People with a history of nerve-related bladder problems, active inability to urinate, or any other condition that prevents normal urination
• People with an active urinary tract infection that, in the treating doctor's opinion, cannot be treated and cleared before the biopsy or study treatment
• People who do not wish to participate
• People who have a known positive HIV test result
• Women who are pregnant or breastfeeding
• Women of childbearing potential who are not using adequate contraception

Important: Always verify eligibility with the trial site directly before applying.