Chronic Kidney Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have chronic kidney disease with kidney function measured at a specific level (eGFR between 15 and 60) — your doctor can confirm this from your blood test results
• Your water tablet (diuretic) and blood pressure medication doses have been stable and unchanged for at least the past 6 weeks

For the salt reduction part of the trial only:

• Your blood pressure reading taken at the clinic (top number) is above 135 mmHg

For the water intake part of the trial only:

• Your kidney function is at a more reduced level (eGFR between 15 and 29) — your doctor can confirm this
• Your blood pressure is 140/90 mmHg or higher, or you are already taking blood pressure medication
• A urine concentration test taken first thing in the morning while fasting shows your urine is below a certain concentration level (confirm with trial site)

Who may not be able to join:

• You are under 18 years old
• You are expected to need dialysis or a kidney transplant within the next 3 months
• You currently have nephrotic syndrome (a condition where the kidneys leak large amounts of protein)
• You have had a kidney inflammation condition (glomerulonephritis) within the past year
• You have a condition where your kidneys cannot hold onto salt (salt-losing nephropathy)
• You are taking steroid tablets or steroid injections (such as prednisolone) at a dose above 5mg per day
• You are unable to have an MRI scan for any reason
• You have had a heart attack, stroke, or heart/blood vessel surgery in the past 3 months
• You are pregnant, planning to become pregnant during the trial, or are of childbearing age and not using contraception
• You are currently taking part in another clinical trial involving a treatment or medication
• You have a serious illness where life expectancy is less than one year
• You have a condition that affects your ability to fully understand and agree to take part in the trial
• You have an active infection or an autoimmune disease affecting your legs or feet
• The trial doctor has any other concern that joining could be harmful to you or affect the results (confirm with trial site)

For the salt reduction part of the trial only:

• You regularly take anti-inflammatory painkillers such as ibuprofen or naproxen (NSAIDs)

For the sodium excretion (salt removal) part of the trial only:

• Your blood potassium level is above a certain level (5.0 mmol/L) — your doctor can check this
• Your kidney function is below a certain level (eGFR under 30) — your doctor can confirm this
• Your blood pressure is very high and uncontrolled (above 180/100 mmHg)
• You have severe heart failure with significantly reduced heart pump function
• You have a reason you cannot take the study medications (confirm with trial site)
• You experience severe dizziness or faintness, especially when standing up
• You have a blockage or narrowing of the heart's outflow, such as aortic valve stenosis
• You have persistently low levels of potassium, sodium, or high calcium in your blood that have not responded to treatment
• You have severe liver disease (confirm with trial site)
• You regularly take anti-inflammatory painkillers such as ibuprofen or naproxen (NSAIDs)

For the water intake part of the trial only:

• Your sodium (salt) blood level dropped very low (below 130 mmol/L) at any point in the past 6 months
• Your sodium blood level is below 135 mmol/L at the time of screening
• You have a history of heart failure
• You take certain medications including lithium, or specific drugs affecting water regulation in the body, steroid tablets/injections, or thiazide water tablets (confirm with trial site)
• Your urine output over a full day is more than 2 litres
• You regularly take anti-inflammatory painkillers such as ibuprofen or naproxen (NSAIDs)

Important: Always verify eligibility with the trial site directly before applying.