Phase 3 Brain Cancer Trial, Recruiting (NCT07021339)

Phase 3 Brain Cancer Trial, Recruiting NCT07021339 Sponsor: University Hospital, Bonn Condition: Brain Cancer

Printed from Voxsanity (voxsanity.com.au) — NCT07021339 — Data sourced from ClinicalTrials.gov. Verify directly with the trial site before attending. Not medical advice.

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Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

Your brain scan (MRI) shows a suspected type of brain tumor called glioblastoma that lights up with contrast dye
A tissue sample taken during surgery confirms a newly diagnosed aggressive (high-grade) brain tumor
Your tumor is located in the temporal lobe (a specific region of the brain) within certain distance limits depending on which side of your brain controls language (confirm with trial site for exact measurements)
Your surgeon believes the entire visible tumor can be completely removed during surgery
Any other areas of concern seen on your brain scan beyond the main tumor are judged by your surgeon to be unrelated to the tumor
You are aged 18 or older but under 75 years old
You are able to carry out most daily activities without significant difficulty (measured by a medical scale called the Karnofsky Performance Scale)
Your doctors estimate you have a life expectancy of at least 6 months
You are able to understand the study and give written consent to participate
You are mentally able to understand why the treatment and procedures are needed
You are able to attend follow-up appointments and live close enough to the trial site to do so
If you could become pregnant, you must have a negative pregnancy test at the start of the trial and agree to use highly effective contraception during the trial and for 3 months after
Your blood tests show your bone marrow, liver, and kidneys are working well enough to safely receive chemotherapy and surgery
Your blood clotting tests are within acceptable ranges; if you take blood-thinning medications, specific tests must show the medication is not actively affecting your blood at the time of surgery, and it must be safe to stop the medication for at least one week after surgery

Who may not be able to join:

Your tumor is not located within the required distance from the front of the temporal lobe (confirm with trial site)
Your surgeon does not believe a complete removal of the tumor is achievable
Your blood test results show your bone marrow, liver, or kidneys are not functioning well enough for safe chemotherapy or surgery
Your blood clotting results fall outside the acceptable ranges and cannot be safely managed before surgery
You are under 18 or 75 years of age or older
Your general health and ability to perform daily activities falls below the required level
Your life expectancy is estimated to be less than 6 months
You are pregnant or unwilling to use effective contraception during and after the trial (if applicable)
You are unable to understand or consent to the study procedures
You are unable to attend regular follow-up visits or live too far from the trial site

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.

Last synced 19 July 2026

Phase 3: approximately ~65% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.

Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

GP referral letter

Print a one-page summary to share with your doctor.

Voxsanity

Clinical trials and treatments, explained plainly · voxsanity.com.au

Date:

To: My Doctor

Re: Clinical trial enquiry

I am writing to enquire about the following clinical trial which may be relevant to my care:

Trial: NCT07021339

Sponsor: University Hospital, Bonn

Phase: Phase 3

Status: Recruiting

Condition: Brain Cancer

More information: https://clinicaltrials.gov/study/NCT07021339

Eligibility summary (AI generated)

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

Your brain scan (MRI) shows a suspected type of brain tumor called glioblastoma that lights up with contrast dye
A tissue sample taken during surgery confirms a newly diagnosed aggressive (high-grade) brain tumor
Your tumor is located in the temporal lobe (a specific region of the brain) within certain distance limits depending on which side of your brain controls language (confirm with trial site for exact measurements)
Your surgeon believes the entire visible tumor can be completely removed during surgery
Any other areas of concern seen on your brain scan beyond the main tumor are judged by your surgeon to be unrelated to the tumor
You are aged 18 or older but under 75 years old
You are able to carry out most daily activities without significant difficulty (measured by a medical scale called the Karnofsky Performance Scale)
Your doctors estimate you have a life expectancy of at least 6 months
You are able to understand the study and give written consent to participate
You are mentally able to understand why the treatment and procedures are needed
You are able to attend follow-up appointments and live close enough to the trial site to do so
If you could become pregnant, you must have a negative pregnancy test at the start of the trial and agree to use highly effective contraception during the trial and for 3 months after
Your blood tests show your bone marrow, liver, and kidneys are working well enough to safely receive chemotherapy and surgery
Your blood clotting tests are within acceptable ranges; if you take blood-thinning medications, specific tests must show the medication is not actively affecting your blood at the time of surgery, and it must be safe to stop the medication for at least one week after surgery

Who may not be able to join:

Your tumor is not located within the required distance from the front of the temporal lobe (confirm with trial site)
Your surgeon does not believe a complete removal of the tumor is achievable
Your blood test results show your bone marrow, liver, or kidneys are not functioning well enough for safe chemotherapy or surgery
Your blood clotting results fall outside the acceptable ranges and cannot be safely managed before surgery
You are under 18 or 75 years of age or older
Your general health and ability to perform daily activities falls below the required level
Your life expectancy is estimated to be less than 6 months
You are pregnant or unwilling to use effective contraception during and after the trial (if applicable)
You are unable to understand or consent to the study procedures
You are unable to attend regular follow-up visits or live too far from the trial site

Important: Always verify eligibility with the trial site directly before applying.

Access in Australia: A treatment being studied in a clinical trial is generally not yet listed on the PBS. Where a medicine is not approved or not available through a trial, the TGA Special Access Scheme may allow a doctor to access unapproved therapeutic goods for individual patients. See voxsanity.com.au/sas-navigator/ for a plain English explainer.

This information was sourced from ClinicalTrials.gov via Voxsanity (data last synced 19 July 2026). It is not medical advice. Please verify the trial's current status directly with the trial site before acting.

Trial details

Status

Recruiting

Phase

Phase 3

Sponsor

University Hospital, Bonn

Registry

ClinicalTrials.gov

Start date

28 November 2024

Est. completion

28 February 2028

Where this trial is recruiting

🇩🇪 Germany

Primary endpoints

Overall survival; Patient-reported Quality of Life

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 19 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov