Phase 2 Sickle Cell Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are at least 18 years old
• You have been diagnosed with sickle cell disease (any type or form)
• Your blood test shows a ferritin (iron) level of 400 ng/mL or higher — OR — your ferritin level is below 400 ng/mL but you have heart-related symptoms such as shortness of breath or swelling in your legs (confirm with trial site)
• You are willing to have regular heart tests, including echocardiograms, ECGs, and cardiac MRI scans
• You are generally able to carry out daily activities with no more than mild limitations (confirm with trial site)
• You are able to read, understand, and sign a consent form
• Your doctor has agreed that it is appropriate for you to take part

Who may not be able to join:

• You are unable to attend the required follow-up appointments
• You have been diagnosed with heart failure
• You have unstable angina (chest pain that is not controlled)
• You have an irregular heartbeat that is not under control
• You have recently had a blood clot in your lungs (acute pulmonary embolism)
• You currently have an active infection or another serious health condition that the trial doctors feel would prevent safe participation
• You have had a bad reaction to chelation therapy (treatment to remove excess iron) in the past, or have a medical reason not to use it
• You have severe kidney or liver problems
• You are currently pregnant or breastfeeding

Important: Always verify eligibility with the trial site directly before applying.