Phase 2 Bladder Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are between 18 and 75 years old at the time of joining the trial
• People who have been diagnosed (confirmed by laboratory testing of tissue or cell samples) with advanced or spread-out bile duct or gallbladder cancer (specifically intrahepatic cholangiocarcinoma, extrahepatic cholangiocarcinoma, or gallbladder carcinoma)
• People whose cancer cannot be removed by surgery and is not able to be cured
• People who have at least one tumour that can be measured using standard imaging guidelines
• People who are reasonably active and able to carry out daily activities, as assessed by a standard medical scoring system (ECOG score of 0 or 1 — confirm with trial site)
• People who are expected to live for at least 12 weeks
• People who have not previously received chemotherapy, immunotherapy, or anti-blood-vessel-targeting therapy for their advanced cancer (people who completed a prior preventative course of therapy more than 6 months ago may still be eligible — confirm with trial site)
• People whose blood counts and bone marrow are working well enough, based on specific blood test results
• People whose liver is functioning well enough, based on specific blood test results
• People whose kidneys are functioning well enough, based on specific blood test results
• People who have read and signed a consent form agreeing to take part

Who may not be able to join:

• People whose cancer is a mixed tumour type or contains a specific rare cell type called neuroendocrine
• People who have active cancer spread to the brain or spinal cord (people with previously treated and stable brain metastases for more than 4 weeks may still be considered — confirm with trial site)
• People who have had another type of cancer in the past 5 years, with some exceptions such as certain treated skin cancers or early-stage cancers that were fully treated
• People who have an active autoimmune disease (where the immune system attacks the body) that requires ongoing medical treatment
• People who have had a severe allergic reaction to medicines similar to those used in this trial
• People with high blood pressure that remains above 140/90 mmHg even with medication
• People with serious heart conditions, including unstable chest pain, a heart attack within the past 6 months, or significant heart failure
• People who have active bleeding, a tendency to bleed, blood clots, or who are taking blood-thinning medicines
• People who have had major surgery in the past 4 weeks or minor surgery in the past 2 weeks
• People who have an active infection currently being treated with medicines
• People who are pregnant or breastfeeding
• People who have HIV, or active hepatitis B or C infection
• People with a psychiatric condition that may make it difficult to follow the trial requirements

Important: Always verify eligibility with the trial site directly before applying.