Phase 2 Leukaemia Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who fully understand the study, choose to take part voluntarily, and sign a consent form
• People aged between 18 and 65 years old
• People who have been diagnosed with acute myeloid leukemia (a type of blood cancer, but not a specific subtype called APL) that has not yet been treated, and who also meet at least one of the following: their leukemia developed from a prior blood condition (secondary AML); their leukemia developed as a result of previous cancer treatment (therapy-related AML); their leukemia has spread outside the bone marrow to form a tumour (myeloid sarcoma); or they are aged 60 or older and have been assessed by doctors as healthy enough to receive intensive treatment
• People whose heart is working well, with the heart's pumping strength (called ejection fraction) at 50% or above
• People whose liver and kidney blood test results fall within acceptable ranges as determined by the trial team
• People whose general health and ability to carry out daily activities is rated at a level of 0, 1, or 2 on a standard medical scale (where 0 means fully active and 2 means able to care for oneself but unable to do physical work)

Who may not be able to join:

• People whose leukemia has been assessed by doctors as making them too unwell or too frail to tolerate intensive treatment
• People who have, or have had, another type of cancer that currently requires treatment
• People with serious uncontrolled health conditions, such as a severe active infection or high blood pressure that cannot be managed
• People who have had a significant allergic reaction to medications in the same family as the drugs used in this trial
• People who are pregnant or breastfeeding, or people who are unwilling to use reliable contraception throughout the study period
• People with a history of serious neurological or psychiatric conditions
• People with serious heart conditions, such as a previous heart attack, severe chest pain, or serious heart rhythm problems
• People who have had a stroke or a temporary stroke-like episode (confirm with trial site)
• People with a known HIV infection, or an active hepatitis B or C infection (note: people who are inactive carriers of hepatitis, or who have low virus levels while receiving certain antiviral treatments, may not be automatically excluded — confirm with trial site)
• People who have taken certain medications or consumed certain foods that affect how the body processes drugs (specifically, strong or moderate CYP3A inducers or inhibitors, or strong P-gp inhibitors) within the 7 days before starting the trial treatment
• People who are unable to swallow tablets or capsules, or who have a condition that prevents the body from properly absorbing oral medications
• People whom the trial doctors determine are not suitable for the study for any other reason

Important: Always verify eligibility with the trial site directly before applying.