Phase 2 Bladder Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People whose cancer can be measured or tracked by researchers to see if it changes over time
• People for whom existing standard cancer treatments are not suitable or are no longer an option
• People who have a tumor tissue sample available for lab testing, or who are willing to have a biopsy taken safely
• People diagnosed with locally advanced, recurring, or metastatic cancer that cannot be cured
• (Part 1) People with most types of solid tumors — except brain cancer — where the cancer has continued to grow, stopped responding to standard treatment, or where treatment side effects were too severe, and a clinical trial is being considered as a next step
• (Part 1) People with specific advanced or metastatic cancers including colorectal cancer, small cell lung cancer, head and neck cancer, non-small cell lung cancer, pancreatic cancer, or bladder cancer — some requiring a specific gene mutation in the cancer
• (Part 1) People with selected solid tumor types — except brain cancers — where the cancer carries a specific gene mutation
• (Part 2) People with specific advanced or metastatic cancers including colorectal cancer, small cell lung cancer, or head and neck cancer — some requiring a specific gene mutation in the cancer
• (Part 2) People with selected solid tumor types — except brain cancers — where the cancer carries a specific gene mutation
• People whose blood and urine test results meet the required levels
• People of childbearing potential who are using adequate contraception
• People who are willing and able to provide written informed consent and follow the study requirements

Who may not be able to join:

• People who are unable to swallow pills
• People with a known history of HIV, hepatitis C (HCV), or hepatitis B (HBV), unless the condition has been cured or is well controlled with an undetectable viral load
• People with an active tumor in the brain
• People with significant liver disease
• People with significant diseases affecting the stomach or digestive system
• People who have had another type of cancer within the past 5 years, with some exceptions for cancers considered likely to be cured
• People with significant heart disease
• People with other poorly controlled health conditions that could make taking the study drug unsafe
• People who are pregnant or currently breastfeeding
• People who have recently received certain anti-cancer or other specific medications within a set period before the study drug would begin (confirm with trial site for exact timeframes)

Important: Always verify eligibility with the trial site directly before applying.