Phase 1 Head and Neck Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are willing to sign a consent form agreeing to take part
• You have head and neck cancer (in the mouth, throat, or voice box area) that has come back or spread to other parts of the body
• You are 18 years old or older and are generally able to carry out daily activities with little or no difficulty (confirm with trial site)
• Your cancer got worse within 24 weeks of your last immunotherapy treatment (with or without platinum-based chemotherapy)
• You have at least one measurable area of cancer that can be tracked during the trial
• You may be asked to provide a tissue sample for a protein test (PD-L1), if one has been done before
• You are expected to live for more than 3 months
• Your blood, kidney, liver, and clotting test results meet certain minimum health levels within 7 days before joining (confirm with trial site for specific numbers)

Who may not be able to join:

• Your cancer could be treated with a local procedure (such as surgery or radiation to one area)
• You have another type of cancer at the same time
• Your cancer has spread to the brain
• You still have significant side effects from a previous treatment that have not cleared up (excluding long-term, ongoing side effects)
• You have a known allergy to any ingredient in the trial medications
• You have had major surgery, radiation therapy, chemotherapy, immunotherapy, or certain other cancer treatments within the 4 weeks before joining
• You have received certain other cancer treatments (including targeted therapy or immune-boosting drugs) within the 2 weeks before joining
• You have taken immune-suppressing medications within the 4 weeks before joining (certain short-term or low-dose exceptions may apply — confirm with trial site)
• You have an active infection requiring antibiotics, active tuberculosis, active hepatitis C, significant hepatitis B levels in your blood, or HIV
• You have fluid build-up around your lungs, abdomen, or heart that cannot be controlled
• You have previously had a severe immune-related side effect from immunotherapy (serious inflammation of any organ, or heart inflammation of moderate severity or worse)
• You have had a serious heart or blood vessel problem within the last 6 months (such as heart failure, heart attack, stroke, or blood clots), have certain abnormal heart test results, or have uncontrolled high blood pressure
• You have an active autoimmune disease (a condition where your immune system attacks your own body)
• You have a significant risk of serious bleeding
• You have received a live vaccine within 4 weeks before joining
• You are pregnant, breastfeeding, or able to have children but not using contraception
• You have a mental health condition that could affect your ability to take part in the trial
• You have had an organ transplant or stem cell transplant in the past

Important: Always verify eligibility with the trial site directly before applying.