Phase 3 Lung Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older
• You have been diagnosed with a type of lung cancer called non-small cell lung cancer (NSCLC) — either squamous or non-squamous — that is advanced or has spread to other parts of the body (stage IIIB–IV), confirmed by a tissue test, and has not been treated yet for this advanced stage
• Your cancer has been tested and shows a result for a protein called PD-L1, and surgery or combined chemotherapy-radiation treatment aimed at curing the disease is not an option for you
• If you had treatment in the past for an earlier stage of the same cancer, that treatment must have finished at least 6 months before starting this trial
• You are generally well enough to carry out light daily activities (your doctor will assess this using a standard scale called ECOG, scored 0 or 1)
• You have at least one measurable tumor that can be tracked on scans
• Your blood tests show that your heart, liver, kidneys, and other organs are working well enough (specific values will be checked at your screening visit)
• If cancer has spread to your brain, it must be stable, not causing symptoms, already treated, and you must not have needed steroid medication for it for at least 2 weeks before starting the trial
• You are able to provide a tumor tissue sample — either from stored tissue or a new biopsy
• If you are male, you agree to use contraception from the first dose until at least 90 days after the last dose, and not to donate sperm during this time
• If you are a woman who could become pregnant, you are not currently pregnant or breastfeeding, and you agree to use contraception throughout the treatment period and for at least 180 days after the last dose

Who may not be able to join:

• Your lung cancer has specific genetic changes known as EGFR, ALK, or ROS1 mutations
• You have advanced (locally advanced) disease but could still receive other treatments that might cure it, such as access to approved immunotherapy
• You have previously been treated with certain immune-based drugs that target PD-1, PD-L1, or similar immune checkpoint proteins
• You have received a live vaccine (for example, for flu or other infections) within 28 days before starting the trial
• You have certain serious underlying health conditions that could make the trial treatment unsafe — such as a history of lung inflammation (interstitial lung disease or pneumonitis), or a current serious infection requiring IV antibiotics or antifungals within 14 days of starting treatment (confirm with trial site)
• You currently need high doses of steroid medications (more than 10 mg/day of prednisone or equivalent) or other medicines that suppress the immune system
• You currently have active hepatitis B, hepatitis C, or HIV infection
• You have a known allergy or sensitivity to any ingredient in the trial medicines
• You have a known history of an autoimmune disease and are currently taking medicines to suppress your immune system
• You have been diagnosed with another cancer within the past two years
• Your expected survival is three months or less
• If you are a woman who could become pregnant, a pregnancy test taken within 72 hours before starting treatment must be negative

Important: Always verify eligibility with the trial site directly before applying.