Phase 2 Lung Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have signed a consent form agreeing to take part in the study.
• You are 18 years of age or older.
• You have been diagnosed with an advanced or spreading type of lung cancer (non-squamous, non-small cell) that cannot be treated with curative treatments.
• Your lung cancer has been confirmed to have a specific gene change called an EGFR sensitizing mutation through a lab test.
• You are able to provide tumor tissue and blood samples for additional lab testing.
• Your cancer has stopped responding to treatment with all three generations of EGFR-targeted pills (known as EGFR TKIs).
• You are in reasonably good general health (able to carry out normal daily activities with little or no limitation) and are expected to live at least 12 more weeks.
• If you have cancer that has spread to the brain, any related brain surgery or radiation must have been completed at least 2 weeks before starting the trial, with side effects mostly resolved, and you must not have needed steroids or fluid-reducing medications for at least 4 weeks.
• You have at least one area of cancer in your body that can be measured on a scan.
• Your blood counts and organ function (such as liver and kidneys) are at acceptable levels before starting the trial.

Who may not be able to join:

• Your lung cancer has features of, or has changed into, a different type called small cell lung cancer.
• You received immunotherapy, antibody-based treatments, or similar cancer drugs within 4 weeks before starting the trial.
• You received chemotherapy, other anti-cancer drugs, or experimental treatments within 14 days before starting the trial.
• You received targeted radiation therapy within 7 days, or extensive radiation (including to large areas of bone marrow) within 28 days, before starting the trial.
• You are currently taking — or cannot stop taking — certain medications that strongly affect how the body processes drugs (called CYP3A4 inhibitors or inducers, including some herbal supplements like St. John's Wort) within 2–3 weeks before starting the trial.
• You are currently taking — or cannot stop taking — certain sensitive medications that interact with the study drug within 2 weeks before starting the trial (confirm with trial site).
• You are currently taking — or cannot stop taking — proton pump inhibitors (common heartburn/acid reflux medications) within 1 week before starting the trial.
• You have had major surgery within 4 weeks before starting the trial, or are planning major surgery during the trial.
• You still have side effects (grade 1 or higher, apart from hair loss) from a previous cancer treatment such as chemotherapy or radiation.
• Your cancer has spread in a way that is pressing on your spinal cord, or has spread to the membranes surrounding your brain or spinal cord.
• You have been diagnosed with another cancer within the past 2 years (some exceptions may apply — confirm with trial site).
• You have serious or poorly controlled conditions such as high blood pressure or a bleeding disorder.
• You have an ongoing or active infection, including hepatitis B, hepatitis C, or HIV.
• You have certain heart conditions or abnormalities, including irregular heart rhythms, a history of heart attack or stroke within the past 6 months, or a family history of certain heart rhythm problems (confirm with trial site).
• You have a history of deep vein blood clots or blood clots in the lungs within 4 weeks before starting the trial.
• You have a history of a lung condition called interstitial lung disease, or currently have active lung inflammation.
• You have ongoing severe nausea or vomiting, a chronic gut condition, difficulty swallowing, or have had part of your intestine removed in a way that might affect how your body absorbs the study medication.
• You have received a live vaccine within 4 weeks before starting the trial.

Important: Always verify eligibility with the trial site directly before applying.