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Back to Head And Neck Cancer
Head and Neck Cancer Trial, Recruiting
NCT07071727
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People who have been diagnosed with an intermediate to high grade soft tissue sarcoma (a type of cancer in the body's connective tissues) located in the head and neck, trunk, chest wall, or limbs, where the standard treatment plan includes both radiation therapy and surgery (this applies when the tumour is deep, 5cm or larger, expected to have a close surgical margin, or is grade II or III by a specific grading system)
- People whose cancer has not spread to nearby lymph nodes or other parts of the body, confirmed by at least a chest CT scan (other scans such as FDG-PET or full-body MRI may also be used)
- People with a WHO Performance Status score of 2 or less, meaning someone who is able to carry out basic daily activities, even if not fully active (confirm with trial site)
- People who are willing and able to undergo radiation therapy before surgery
- People who are willing and able to undergo the planned surgical removal of the tumour
- People who are willing and able to attend regular follow-up appointments after treatment
- People who are willing and able to complete questionnaires about their quality of life and related health costs
- People who are willing and able to be randomly assigned to a treatment group
- People aged 18 years or older
- People who have signed a written consent form agreeing to participate
Who may not be able to join:
- People who have had a previous cancer diagnosis, unless they have been free of that cancer for 5 or more years, or unless it was a fully removed non-melanoma skin cancer, or a successfully treated early-stage (in situ) cancer
- People whose sarcoma has come back in the same area after a previous diagnosis (locally recurrent sarcoma), regardless of how the first diagnosis was treated
- People diagnosed with specific sarcoma subtypes: Ewing sarcoma, other PNET family tumours, rhabdomyosarcoma (in children or adults), or osteosarcoma
- People diagnosed with myxoid liposarcoma, as this subtype responds well to lower radiation doses that differ from those being tested in this trial
- People who have personal, psychological, family, social, or location-based circumstances that may make it difficult to follow the study schedule and attend appointments (the trial team would discuss this with the person before enrolment)
- People who are pregnant
- People whose planned procedure is an isolated limb perfusion (a specific treatment technique) rather than surgical tumour removal
- People who are planned to receive chemotherapy both before and after radiation therapy
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
This study is not part of the standard drug-approval phase pathway (for example an observational, device, behavioural, or registry study), so a phase success rate does not apply.
Contact this trial
Phone: +31205129111
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Status
Recruiting
Phase
Not Applicable
Sponsor
The Netherlands Cancer Institute
Registry
ClinicalTrials.gov
Start date
11 December 2025
Est. completion
1 November 2028
Where this trial is recruiting
🇳🇱 Netherlands
Primary endpoints
The short-term toxicity
Can't join this trial?
Data last synced from ClinicalTrials.gov: 8 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.
Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.