Early Phase 1 Long COVID Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You must be 18 years old or older.
• You must be able to understand what the trial involves and be willing to sign a consent form.
• You must be willing and able to follow all the procedures required by the trial.
• If you are able to have children (have had a period in the last 24 months or have not had certain sterilization surgeries), you must be willing to use two effective forms of birth control during the study and for 1 day after the last imaging procedure.
• You must have previously tested positive for COVID-19, either through a lab-based test or an FDA-approved at-home rapid antigen test (documentation is requested but not required — you can confirm it yourself).
• Your COVID-19 symptoms (or positive test, if you had no symptoms) must have started at least 3 months before your first study visit.
• You must be able to travel to research sites in San Francisco or Sacramento.
• Your recent blood test results (within the last 60 days) must show that your blood counts and organ function (including blood cells, liver, and kidneys) are within acceptable levels (confirm specific numbers with trial site).
• If joining as a Long COVID participant: You must have at least 2 unexplained ongoing symptoms lasting at least 2 months — at least one must be tiredness/fatigue, and at least one must relate to the heart/lungs or brain/thinking, with no other explanation for these symptoms, following the World Health Organization's definition of Long COVID.
• If joining as a control participant: You must have fully recovered from COVID-19 within 4 to 12 weeks of being infected, with no new symptoms or health changes after recovery.

Who may not be able to join:

• You have serious health conditions (other than cancer) that the study doctor believes could interfere with the trial.
• You have a condition that affects how your immune system works, such as a known inflammatory disorder, active cancer, or a long-term viral infection like HIV, hepatitis B, or hepatitis C.
• You have received any vaccine, including a COVID-19 vaccine, within 30 days before the imaging appointment.
• You are currently pregnant or breastfeeding (a pregnancy test will be offered at no cost to those who could potentially be pregnant).
• You have previously had a bone marrow transplant or an organ transplant from another person.
• You have been diagnosed with certain blood or bone marrow disorders (myelodysplasia syndrome or lymphoproliferative disease) (confirm with trial site).
• You have an active autoimmune disease that is not related to COVID-19.
• You have severe claustrophobia (fear of enclosed spaces) that is not under control, as the study involves lying inside a scanner.
• You have had a PET scan as part of another research study within the last 12 months.
• You weigh more than 240 kg (529 pounds).
• You are currently in prison.
• Your life expectancy is less than 24 months.
• You are currently taking or have recently taken certain medications, including guanosine or cysteine analogs (confirm with trial site).
• The study doctor determines for any other reason that joining the trial would not be appropriate for you.

Important: Always verify eligibility with the trial site directly before applying.