PTSD Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are right-handed
• People who have normal vision, or vision that is fully corrected with glasses or contact lenses, and a normal sense of smell
• People who are between 18 and 50 years old
• People who pass a safety screening checklist for a brain stimulation procedure called tACS (for example, no serious head injury history — confirm with trial site for the full list)
• For patients: People who have been diagnosed with PTSD
• For patients who take psychiatric medications: People whose medication doses have been stable for at least the past 2 months
• People who use substances occasionally, or patients with mild substance use disorder, who are able to stop use at least 48 hours before the experiment

Who may not be able to join:

• People who have been diagnosed with a major medical illness (such as cancer, metabolic conditions, heart disease, or inflammatory disorders) or a neurological condition (such as epilepsy/seizures, stroke, or Parkinson's disease)
• For patients: People who have another major mental health diagnosis at the same time — though depression, anxiety, and mild substance use disorder are generally allowed given how commonly they occur alongside PTSD (confirm with trial site)
• For healthy volunteers (non-patients): People who have ever been diagnosed with a DSM-5 mental health disorder, or who are currently taking any psychiatric medications
• People who are in severe psychiatric crisis, including anyone who is actively having thoughts of harming themselves or others, or whose behaviour poses an immediate danger
• People who have had a head injury that caused them to lose consciousness for more than 5 minutes
• People who regularly drink 3 or more alcoholic drinks per day
• People who are not able to stop using substances (including alcohol, nicotine, cannabis, amphetamines, narcotics, solvents, cocaine, hallucinogens, tranquilisers, barbiturates, or similar) or sleep medications for 48 hours before the scan
• People who take certain blood pressure medications called calcium channel blockers (such as verapamil or nifedipine) or alpha-blockers (such as prazosin or terazosin) and are not able to pause those medications for 48 hours before scanning
• People who do not pass a urine drug screening test conducted before participation
• People who are pregnant, as confirmed by a urine test — the safety of MRI scanning for unborn babies has not been fully established
• People who have any electrically, magnetically, or mechanically activated implanted devices (such as a cardiac pacemaker), because the MRI equipment may interfere with how those devices work

Important: Always verify eligibility with the trial site directly before applying.