Phase 2 Lung Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 to 75 years, male or female.
• People with a laboratory-confirmed diagnosis of non-small cell lung cancer (either squamous or non-squamous type, with the non-squamous type testing negative for certain genetic markers called EGFR, ALK, and ROS1).
• People who have not previously received any surgery, radiotherapy, chemotherapy, targeted therapy, immunotherapy, cell therapy, traditional Chinese medicine for cancer, or any other cancer treatment.
• People whose cancer has been assessed by a specialist team as unresectable (unable to be removed by surgery) at stage III, based on a specific lung cancer staging system (confirm with trial site).
• People who have at least one measurable area of cancer visible on a chest CT scan or PET/CT scan.
• People with a general health and activity level rated as 0 or 1 on the ECOG scale, meaning fully active or restricted only in strenuous activity (confirm with trial site).
• People whose overall health is considered suitable enough to tolerate the planned treatment and surgery.
• People with an expected survival of at least 12 months.
• People whose blood counts, liver, kidney, thyroid, and clotting function all meet specific levels required by the trial (confirm exact values with trial site).
• People whose lung and heart function meet specific minimum levels required by the trial (confirm exact values with trial site).
• Women who could become pregnant must have a negative pregnancy test within 7 days before joining and must agree to use reliable contraception during the trial and for 8 weeks after the last dose; men must agree to use reliable contraception during the trial and for 8 weeks after the last dose, or must have had a surgical sterilisation procedure.
• People who voluntarily agree to participate, sign a consent form, and are willing to attend follow-up appointments.

Who may not be able to join:

• People who have a medical reason that makes immunotherapy unsuitable, such as long-term use of steroid medications or a history of radiation-related lung inflammation.
• People with a known history of severe allergic reactions to paclitaxel, docetaxel, platinum-based chemotherapy drugs, or medications used to prevent reactions to these drugs.
• People with any unstable health condition, including active infection, blood pressure that remains too high despite treatment, unstable chest pain (angina), a chest pain episode within the past 3 months, or active liver, kidney, or metabolic disease requiring medication.
• People who received a live vaccine within 28 days before starting treatment.
• People who have previously received radiotherapy, chemotherapy, targeted therapy, or immunotherapy (also listed separately in the inclusion criteria — confirm with trial site).
• People with an active autoimmune disease — a condition where the immune system attacks the body, such as certain skin conditions, psoriasis, or thyroid conditions requiring hormone treatment.
• People with active hepatitis B, active hepatitis C, HIV, or active tuberculosis.
• People with a current infection that requires treatment with antibiotics, antiviral, or antifungal medications.
• People who have had an organ transplant from another person, or a stem cell transplant.
• People with a current or past diagnosis of interstitial lung disease or interstitial pneumonia (a type of lung inflammation or scarring).
• People with a history of drug misuse or mental health conditions that are not well controlled.
• People who currently have or have previously had another cancer that has not been fully treated, except for certain skin cancers, early-stage cervical cancer, or early-stage bladder cancer that have been cured.
• Women who are pregnant or breastfeeding, or people of childbearing potential who are unwilling or unable to use effective contraception.
• People whom the trial investigators judge may not be suitable for other reasons that could affect the trial or its results.

Important: Always verify eligibility with the trial site directly before applying.