Phase 2 Kidney Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You must be 18 years of age or older
• For Groups A and B: You have been diagnosed with bladder cancer or upper urinary tract cancer (confirmed by a tissue biopsy), and your cancer has gotten worse despite treatment with the drugs enfortumab vedotin and pembrolizumab (these treatments do not need to have been given at the same time or right before joining)
• For Group C: You have been diagnosed with bladder cancer or upper urinary tract cancer (confirmed by a tissue biopsy), your cancer has gotten worse after a type of targeted drug treatment called an ADC, and you do not qualify for Groups A or B (patients from Groups A and B whose cancer progressed on that treatment may also be eligible for this group after re-enrolling)
• Your cancer must be measurable on scans, according to a standard set of measurement rules
• You must be reasonably active and able to care for yourself, based on a standard doctor's assessment (scores 0, 1, or 2 on a common medical scale)
• Your blood counts and organ function (blood, liver, and kidney) must meet certain minimum levels, checked within the past 30 days
• If you are capable of becoming pregnant, you must have a negative pregnancy test within 8 days before joining
• You must be willing and able to sign a consent form agreeing to take part
• You must be able to complete questionnaires, either on your own or with help
• You must be willing to receive whichever treatment is assigned to your group
• You must be willing to provide blood, fluid, and tissue samples for research purposes
• You must be willing to return to the trial site for follow-up visits during the study

Who may not be able to join:

• People who are currently pregnant
• People who are currently breastfeeding
• People who are capable of becoming pregnant or fathering a child and are not willing to use reliable contraception during the trial, because the effects of the study drug on an unborn baby or newborn are not yet known
• People whose cancer has certain specific features under the microscope (neuroendocrine features or signet ring cell features), even in small amounts
• People who have had another active cancer in the past 24 months — with some exceptions, including: skin cancers considered fully cured, non-invasive cervical cancer considered fully cured, certain very low-risk breast conditions, or certain low-risk prostate cancers that have been treated or are being closely monitored
• People who have had serious heart or blood vessel problems in the past 6 months, such as severe heart failure, unstable chest pain, a heart attack, certain dangerous heart rhythm problems, a stroke, or a mini-stroke
• People with mental health or personal circumstances (such as substance use) that might make it difficult to follow the trial requirements
• People for whom the trial doctor believes participation would not be in their best interest or could interfere with how the trial is assessed (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.