Chronic Kidney Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 18 and 85 years old (any gender)
• You have chronic kidney failure and have been receiving peritoneal dialysis regularly for at least 3 months, with no major changes to your treatment expected during the trial
• You are able to understand the study, follow its procedures, and are willing to sign a consent form
• During a baseline tracking period, you recorded your itching levels (using a scale) both morning and evening on at least 5 days, and your average itching score was high enough to meet the study's minimum threshold
• During that same baseline period, your itching was rated as moderate or higher on at least 2 of those days (confirm with trial site)

Who may not be able to join:

• You have not been following your dialysis treatment as required, in a way that could affect how the trial results are measured
• Your peritoneal dialysis routine was changed within the 2 weeks before screening
• You are currently on, or planning to start, hemodialysis within the next 2 months
• You have a planned kidney transplant or non-emergency surgery scheduled during the study
• You had a peritoneal infection (peritonitis) within the 4 weeks before screening that stopped you from continuing dialysis
• Your liver function blood test results were significantly above the normal range during screening
• Your itching is caused by something other than chronic kidney disease, such as an allergy, skin infection, or liver condition
• You have serious heart disease, including severe heart failure, a recent heart attack, unstable chest pain, or dangerous heart rhythm problems
• You have had an active cancer in the past 12 months, or have recently received cancer treatments such as chemotherapy, radiotherapy, or immunotherapy
• You have an ongoing infection (such as active tuberculosis or HIV) that is not under control
• Your blood pressure is very high and uncontrolled (top number 180 or above, or bottom number 110 or above)
• You are currently taking steroid tablets or immunosuppressant medicines by mouth or injection (skin creams are generally acceptable)
• You have a psychiatric condition or a cognitive (thinking/memory) disorder
• You have recently started or changed certain medications that could affect itching or the study results — including antihistamines, certain steroids, nerve pain medications, or antidepressants — within 1–2 weeks before screening, or expect to change them during the study
• You have used opioid-type pain medicines within the 2 weeks before screening
• You have had light therapy (phototherapy) for itching within the past month
• You have had a problem with drug or alcohol misuse within the past 12 months
• You are allergic to opioids or to any ingredients in the trial medication
• You have taken part in another clinical trial involving an experimental drug or device within the past 28 days
• You are pregnant, breastfeeding, have a positive pregnancy test, or are unwilling to use contraception during the study
• The trial doctor considers you unsuitable for any other reason

Important: Always verify eligibility with the trial site directly before applying.