Phase 2 Type 2 Diabetes Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 18 and 60 years old (male or female)
• You are considered generally healthy by the study doctor
• Depending on which part of the trial you join: you have a body weight in the normal-to-healthy range (Parts 1), are significantly overweight (Parts 2 and 3), or have been diagnosed with type 2 diabetes (Part 3)
• Your fasting blood sugar level falls within the range required for the part of the trial you are joining (confirm with trial site)
• You do not smoke, or smoke very little (no more than 5 cigarettes or equivalent per day in the past 3 months)
• You are able to avoid alcohol completely for 48 hours before taking the study drug and until your final study visit
• If you are a woman who could become pregnant, you agree to use one highly effective form of contraception plus an additional barrier method throughout the study
• If you are a man who is sexually active, you agree to use a condom from the start of the study until at least 90 days after your last dose (or you have had a surgical procedure making you unable to father children), and any female partner who could become pregnant also uses a highly effective contraceptive
• You are able and willing to give signed consent to take part
• You are willing and able to follow all study rules, including staying at the study clinic when required
• For Part 3 only: you have an established diagnosis of type 2 diabetes managed by diet and exercise alone, or by a stable dose of metformin for at least 2 months

Who may not be able to join:

• You have significant abnormalities in blood count results found at screening (confirm with trial site)
• You have liver problems, including abnormal liver enzyme or related blood test results above certain levels at screening
• You have kidney problems, including reduced kidney function below a certain level at screening
• You have tested positive for COVID-19 (SARS-CoV-2)
• You have a history of seizures that were not caused by a fever
• You have a positive pregnancy test at screening or when admitted to the clinic
• You have had major surgery within the past 60 days, or have major surgery planned during the study
• You have a history of cancer, except for certain skin cancers that have been fully removed by surgery
• You have a known or suspected allergy to the study drug or any of its ingredients
• You have any other condition that the study doctor feels makes you unsuitable for the study
• You have a history or current evidence of any significant illness or medical condition
• You have previously had, or are planning to have, weight-loss surgery (such as gastric bypass or gastric band) or removal of part of the intestine
• You have had a substance use disorder or alcohol misuse in the past 12 months, or you test positive for alcohol at screening or when admitted to the clinic
• You test positive for recreational drugs at screening or when admitted to the clinic
• You have received a live vaccine within 14 days before taking the study drug
• You are currently taking any medications other than paracetamol, including hormonal contraceptives
• You have taken part in another clinical trial or received an investigational drug within the past month or five half-lives of that drug (whichever is longer)
• Your heart's electrical activity shows certain abnormalities on an ECG at screening (confirm with trial site)
• Your blood pressure is above 140/90 mmHg at screening
• You test positive for HIV, hepatitis B, hepatitis C, or syphilis
• Your body weight has changed by 10% or more in the 3 months before screening
• You have donated or had more than approximately 450 mL of blood taken in the 30 days before screening
• For Part 3 only: you have type 1 diabetes, a rare inherited form of diabetes, or any other type of diabetes other than type 2

Important: Always verify eligibility with the trial site directly before applying.