Phase 2 Endometrial Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older
• People who have received a pathology diagnosis within the past 4 months of either low-grade (grade 1) uterine cancer of a specific type (endometrioid endometrial adenocarcinoma) or a pre-cancerous uterine condition called EIN (endometrial intraepithelial neoplasia)
• People whose diagnosis was made at a different hospital or clinic — the trial site will review those records before confirming eligibility
• People whose general physical functioning falls within an accepted range on a standard medical scale (ECOG score 0–3, meaning anywhere from fully active to limited in self-care — confirm with trial site)
• For those with uterine cancer: people whose cancer has not spread outside the uterus or into the uterine wall, as confirmed by MRI or internal ultrasound
• People with a BMI of 30 or higher, AND at least one of the following: significant other health conditions that make surgery higher risk (as assessed by a doctor), or a desire to preserve fertility
• People who have had appropriate breast screening and examinations suitable for their age before joining the trial, as confirmed in their medical records
• People who are willing to provide written consent and agree to follow all trial procedures

Who may not be able to join:

• People with a higher-grade (grade 2 or 3) uterine cancer, or a different type of uterine cancer such as clear cell or serous carcinoma
• People whose doctor suspects the cancer may have spread, or where imaging has confirmed it has spread
• People with abnormal cervical screening results
• People who have been diagnosed with thyroid cancer, pancreatitis, or a condition called multiple endocrine neoplasia syndrome type 2
• People who are currently pregnant or breastfeeding
• People with a personal history of medullary thyroid cancer
• People with a current or past history of cancers that are sensitive to hormones, such as certain breast cancers or melanoma
• People who have already been taking a class of medications called GLP-1 receptor agonists (used for diabetes or weight management) for more than 14 days at the time of joining the trial
• People who have had a hormonal IUD (levonorgestrel-releasing intrauterine device) in place for more than 45 days before joining the trial
• People who have more than one active cancer at the time of joining (some exceptions may apply at the treating doctor's or principal investigator's discretion)
• People with other serious medical conditions, including severe heart failure (NYHA Class IV), that a treating doctor considers would make the trial treatment unsafe or affect the reliability of results
• People who are prisoners, involuntarily detained, or held for compulsory psychiatric or physical health treatment

Important: Always verify eligibility with the trial site directly before applying.