Phase 2 Brain Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 or older, of any gender
• People who have HER2-expressing breast cancer that is advanced or has spread to other parts of the body
• People whose cancer has spread to the membranes surrounding the brain and spinal cord (leptomeningeal metastasis)
• People with active brain tumours must have at least one brain lesion that is large enough to be measured using specific imaging guidelines (confirm with trial site)
• People whose liver, kidneys, and bone marrow are functioning at an adequate level
• People who have not received radiotherapy, chemotherapy, targeted therapy, immunotherapy, hormone therapy, or surgery within the 2 weeks before joining (or within a specific timeframe based on their last treatment, whichever comes first)
• People whose side effects from previous treatments have mostly cleared up, with only mild effects remaining

Who may not be able to join:

• People diagnosed with another cancer in the past 5 years, unless it was a type that has been fully cured, such as certain skin cancers, early-stage cervical cancer, other non-invasive cancers, or papillary thyroid cancer
• People with ongoing serious health conditions that are not well controlled, such as active infections, significant heart or blood vessel problems, severe ongoing diarrhoea, or mental health or social conditions that could make it difficult to follow the trial requirements
• People who have a history of, or currently have, a type of lung inflammation (not caused by infection) that required steroid treatment, or where this condition cannot be ruled out during screening
• People with other significant lung health problems
• People who have used strong immune-suppressing medications or high-dose steroid tablets within the 2 weeks before the first dose (nasal sprays or inhaled steroids are generally not included in this restriction — confirm with trial site)
• People with an active autoimmune disease, or a history of autoimmune disease that could come back
• People with active uncontrolled infections currently needing intravenous (IV) antibiotics, antiviral, or antifungal treatment
• People with a primary immune system disorder, known HIV, active hepatitis B, or active hepatitis C infection (people who have had hepatitis C may still be considered if a specific blood test confirms the virus is no longer active — confirm with trial site)
• People whose scans show that the tumour is wrapped around or growing into major blood vessels, or where doctors consider there to be a high risk of serious bleeding
• People who are pregnant or breastfeeding, or people who are able to have children but are unwilling or unable to use effective contraception during the trial
• People with any other health condition that the trial doctors believe could affect how the trial runs or how results are understood

Important: Always verify eligibility with the trial site directly before applying.