Phase 2 Melanoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years old or older
• You have been diagnosed with metastatic uveal melanoma (a type of eye cancer that has spread), confirmed by a tissue or cell sample
• Your cancer can be measured on a scan, following standard medical guidelines
• You are well enough to carry out everyday activities, with only mild limitations at most (confirm with trial site)
• You have had previous cancer treatments; there is no limit on how many prior treatments you have received
• If you have a specific genetic marker called HLA-A*02:01, you must have previously received a treatment called tebentafusp, unless it was unavailable or not suitable for you (confirm with trial site)
• You have recovered from most or all side effects of previous cancer treatments, and enough time has passed since your last treatment
• Your heart's electrical activity (measured by an ECG) is within an acceptable range
• Your blood counts are at acceptable levels — including red blood cells, platelets, and white blood cells — and you are not dependent on blood transfusions
• Your liver is functioning well enough, based on blood test results
• Your kidneys are functioning well enough, based on blood test results
• If you are able to have children (male or female), you have agreed to use two reliable forms of contraception during the study and for 6 months after your last dose
• You are willing and able to attend scheduled visits and follow the study plan

Who may not be able to join:

• You are pregnant or currently breastfeeding
• You are receiving other cancer treatments at the same time that are not part of this trial (such as chemotherapy, radiation, or other targeted therapies)
• You have had another type of cancer in the past 3 years, with some exceptions for certain low-risk cancers (confirm with trial site)
• You have an active or uncontrolled infection, or a serious illness that would make it difficult to safely take part
• You have a medical condition or finding that could make the study drug unsafe for you or make the results hard to interpret (confirm with trial site)
• You have difficulty swallowing tablets or capsules
• You are currently taking certain medications that strongly affect how a liver enzyme called CYP2C8 works (for example, a drug called gemfibrozil) — confirm your current medications with the trial site
• You have tested positive for hepatitis B or hepatitis C, unless the virus level in your blood is undetectable
• You have had a heart attack, severe chest pain, heart bypass surgery, heart failure, or a stroke (including a mini-stroke) within the past 3 months
• You are taking or expected to need certain medications that affect drug transport in the body (called P-gp or BCRP inhibitors) — confirm with trial site
• You have taken stomach acid-reducing medications (such as proton pump inhibitors or H2 blockers) within the 7 days before starting the trial, or plan to take them during the trial, unless you are able to switch to a suitable antacid taken at specific times around your dose (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.