Osteoporosis Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

Group 1 (Mast Cell Activation) — People who meet the criteria for either of the following:

• People who have had a documented severe allergic reaction (anaphylaxis) to insect stings (such as bees or wasps) that affected the heart or blood circulation, OR a severe allergic reaction with no known cause that required a hospital visit, emergency room care, and/or an adrenaline injection and affected the heart or blood circulation.
• People who experience recurring episodes of symptoms affecting at least 2 body systems — such as the skin, breathing/nose/eyes, digestive system, or heart and circulation — without a known trigger, and who have shown some response to medication aimed at reducing mast cell activity, as determined by the study doctor.

Group 2 (Related Conditions) — People who have a confirmed diagnosis of one of the following:

• A connective tissue condition called hypermobile Ehlers-Danlos syndrome, or a documented history of a related condition called hypermobility spectrum disorder.
• A condition called postural orthostatic tachycardia syndrome (a heart rate disorder when standing), along with one or more symptoms affecting the body more broadly.
• Bone thinning (either osteoporosis or osteopenia) that was diagnosed at age 50 or younger.

Group 3 (Blood Conditions) — People who have a documented diagnosis of one of the following, confirmed using World Health Organization classification guidelines:

• A blood condition called chronic myelomonocytic leukemia, OR a related bone marrow condition classified as myelodysplastic syndrome/myeloproliferative neoplasm not otherwise specified.

Who may not be able to join:

• People who have previously been diagnosed with a specific type of mast cell condition involving a gene change known as a KIT mutation (monoclonal mast cell activation syndrome with KIT mutation).
• People whose mast cell condition affects only the skin, with no confirmed evidence of mast cell disease in the bone marrow.
• People who have been diagnosed with any form of systemic mastocytosis (a condition where mast cells build up in organs throughout the body).
• People who have been diagnosed with mast cell sarcoma (a rare and aggressive mast cell tumour).
• For Group 2 only: People whose bone thinning (osteopenia or osteoporosis) is already explained by a known genetic, hormonal, nutritional, or other medical condition.

Important: Always verify eligibility with the trial site directly before applying.