Phase 2 Brain Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People diagnosed with glioblastoma (a type of brain tumour) that has come back, where the medical team has determined that standard treatments are no longer working
• People whose returning glioblastoma has been confirmed through a laboratory examination of tumour tissue
• People whose brain scan (MRI) shows the returning tumour is larger than 1.0 cm at its widest point
• People who have previously received at least one prior treatment, with enough time having passed since that treatment (for example, more than 28 days since surgery or radiotherapy, or specific waiting periods after certain chemotherapy drugs — confirm exact timing requirements with the trial site)
• People aged 18 to 70 years old
• People whose blood counts, kidney function, and liver function are within normal ranges
• People who are willing to use an approved method of contraception throughout the study and for 180 days after receiving the study treatment
• People who are able to follow the study procedures and provide written consent to participate

Who may not be able to join:

• People who have taken part in another drug clinical trial within the past 4 weeks
• People who have a tendency to bleed easily before surgery, or who are taking blood thinners or other medications that may increase bleeding risk
• People whose cancer has spread to parts of the body outside the brain
• People with poorly controlled liver function, including certain liver enzyme or bilirubin levels that are more than twice the normal upper limit
• People who are currently pregnant or breastfeeding
• People with an active uncontrolled infection, or conditions affecting the immune system such as autoimmune disease, active hepatitis B, hepatitis C, or active HIV infection
• People with a history of misusing substances (such as drugs or alcohol) that they have been unable to stop, or people with a diagnosed mental health disorder
• People with any active autoimmune disease or a history of autoimmune disease
• People who have used antiviral medications within the past week
• People who are currently receiving immunosuppressive therapy, chemotherapy, radiation, or biological therapy
• People who cannot safely have an MRI scan — for example, those with pacemakers, certain metal implants, surgical clips, shrapnel, or metal objects in the eye (confirm specifics with the trial site)
• People who have received a vaccination within 30 days before starting the study treatment
• People who have previously received gene therapy or any type of oncolytic virus treatment
• People with a history of brain or nervous system infections such as encephalitis, multiple sclerosis, or other central nervous system conditions
• People who are unwilling to use contraception during the study and for 6 months after receiving the treatment
• People who, in the investigator's judgement, have a serious health condition that could put them at risk or prevent them from completing the study

Important: Always verify eligibility with the trial site directly before applying.