Phase 1 Head and Neck Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with head and neck squamous cell cancer (in the mouth, throat, voice box, or nearby areas) that has come back or is a new cancer in the same region, and cannot be removed by surgery — either because you declined surgery or a specialist determined surgery is not possible or safe.
• Your cancer has come back in an area of your body that was previously treated with radiation therapy.
• You finished your previous radiation treatment at least 6 months before joining this trial.
• You have at least one measurable tumor that can be seen on a scan (such as a CT or PET scan).
• You are 18 years of age or older.
• You are well enough to carry out basic daily activities (your doctor can confirm this using a standard health scale).
• Your blood cell counts are at healthy enough levels — including white blood cells, infection-fighting cells (neutrophils), platelets, and red blood cells — as shown by recent blood tests.
• Your liver is functioning well enough, as shown by blood test results within acceptable ranges.
• Your protein levels (albumin) in the blood are above a minimum level.
• Your kidneys are working well enough, based on a kidney function measurement.
• If you have HIV, you are on effective treatment and your virus levels are undetectable within the past 6 months.
• If you have chronic hepatitis B, your virus levels are undetectable while on appropriate treatment.
• If you have had hepatitis C, you have been successfully treated and cured, or are currently on treatment with undetectable virus levels.
• If you have or have had another type of cancer, it does not interfere with this trial's treatment or assessments (confirm with trial site).
• If you have a history of heart problems or have been treated with medicines that affect the heart, your heart function must meet a minimum standard as assessed by your doctor.
• You are able to swallow pills by mouth.
• If you are a woman who could become pregnant, or a man whose partner could become pregnant, you must agree to use effective birth control during the trial and for 6 months after finishing the study drug.
• You are willing and able to give written informed consent to participate.

Who may not be able to join:

• You are still experiencing significant side effects from a previous cancer treatment (other than hair loss).
• You are currently taking part in another clinical trial for your cancer.
• Your cancer has spread to distant parts of your body (such as other organs).
• You have previously received more than one course of radiation therapy to the head and neck area that overlaps with where treatment would be given in this trial.
• Your tumor surrounds more than half of a major blood vessel in the neck called the carotid artery.
• Your tumor has grown into the jawbone or has broken through the skin.
• You have had a serious allergic reaction to a drug similar to the study drug (camonsertib), or to radiation therapy.
• You have another serious illness or condition that would make it unsafe for you to participate.
• You are currently pregnant or breastfeeding.
• You have been diagnosed with scleroderma (a connective tissue disease).
• You are currently taking certain medications that strongly interact with the study drug — your doctor or the trial team can review your current medicines to check (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.