Phase 2 Head and Neck Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with a type of throat cancer (oropharyngeal squamous cell carcinoma) that is linked to the HPV virus, confirmed by a specific laboratory test called HPV in situ hybridization.
• People who have not received any prior treatment for this cancer (such as chemotherapy given before the main treatment).
• People whose cancer can be measured or evaluated using standard imaging criteria known as RECIST v1.1.
• People who are 18 years of age or older.
• People whose cancer is classified as Stage I or II (AJCC 8th edition), meaning the tumour falls within certain size and spread categories, and there is no evidence the cancer has spread to other parts of the body (confirmed by physical examination and a PET scan).
• People who have had a PET scan to assess the stage of their cancer before joining the trial.
• People who are generally well enough to carry out normal daily activities, with only minor limitations — rated 0 or 1 on a standard scale doctors use to measure overall health and activity level (ECOG Performance Status).
• People who are planned to receive radiation therapy (RT) either alone or combined with chemotherapy, with chemotherapy decisions made by the treating doctor according to standard care.
• People who are able to become pregnant must agree to use an adequate form of contraception (such as hormonal or barrier methods, surgical methods, or abstinence) from the time of consent and throughout the period of receiving radiation therapy.
• People who are able to become pregnant must have a negative pregnancy test, or sign a standard declination form, before the planning CT scan for radiation therapy.
• People who are able to understand the study information and are willing to sign a written consent form before joining the trial.

Who may not be able to join:

• People whose cancer is classified at a more advanced stage — specifically T4, N3, or M1 under the AJCC 8th edition staging system — meaning the tumour is very large, has spread extensively to lymph nodes, or has spread to other parts of the body.
• People who have previously had radiation therapy to the head or neck area in a way that would overlap with the radiation fields planned for this trial.
• People who have had major surgery to the head or neck area that may have affected the flow of fluid through the lymphatic system, as determined by the lead investigator.
• People who have an uncontrolled ongoing illness that could interfere with receiving radiation therapy, including uncontrolled connective tissue diseases (such as lupus or scleroderma), mental health or social circumstances that would make it difficult to follow the study requirements, or any other condition the treating doctor believes could affect safety or the ability to complete the study.

Important: Always verify eligibility with the trial site directly before applying.