Phase 3 Head and Neck Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged between 18 and 70 years old.
• People who have signed a consent form and are willing and able to attend appointments, follow the treatment schedule, and complete required tests as outlined in the study plan.
• People newly diagnosed with cancer that has spread to distant parts of the body (metastatic), whose cancer showed a complete or partial response after receiving a standard first-line treatment of platinum-based chemotherapy combined with a PD-1 immunotherapy drug.
• People diagnosed with a specific type of nasopharyngeal carcinoma (a cancer at the back of the nose/throat) — specifically the non-keratinizing type (WHO type II or III) — confirmed by tissue or cell testing, with visible spread shown on imaging scans.
• People whose cancer is classified as stage IVB (the most advanced stage, meaning the cancer has spread to distant parts of the body) according to the AJCC 9th edition staging system.
• People with a physical fitness score of 0 or 1 on the ECOG scale, meaning they are either fully active or have only mild limitations in physical activity (confirm with trial site).
• Women who could become pregnant must have a negative pregnancy test (urine or blood) within 7 days before joining, and must agree to use effective contraception throughout the study.
• Men whose partner could become pregnant must agree to use effective contraception throughout the study.

Who may not be able to join:

• People who have fluid around the lungs that is related to cancer, or who have another type of cancer in addition to nasopharyngeal carcinoma.
• People who have already received two or more rounds (lines) of systemic cancer treatment.
• People with a known or suspected autoimmune disease, including conditions such as dementia or epilepsy.
• People with moderate to severe heart conditions, including coronary heart disease, certain abnormal heart rhythms (including specific changes on a heart tracing test), or heart failure.
• People who received steroid medications (glucocorticoids) — either throughout the body or in a specific area — within 4 weeks before joining the trial.
• People who need to take immune-suppressing medications long-term, or who require steroids at doses high enough to suppress the immune system.
• People who currently have active tuberculosis (TB), are being treated for TB, or who received TB treatment within the past year before screening.
• People who are HIV positive; people who test positive for hepatitis B surface antigen with a detectable hepatitis B viral load above a certain level; or people who test positive for hepatitis C antibodies.
• People who received any vaccine (such as a flu shot or chickenpox vaccine) within 4 weeks before joining the trial.
• People whose treating doctor estimates their life expectancy to be less than 6 months at the time of joining the trial.
• People who the treating doctor considers unsuitable for the trial for any other reason.

Important: Always verify eligibility with the trial site directly before applying.