Sickle Cell Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with, or are suspected to have, a hereditary (inherited) type of anemia where red blood cells break down too easily — this includes conditions such as:
• Sickle cell disease
• Thalassemia (a group of inherited blood disorders)
• Congenital dyserythropoietic anemia (a rare inherited condition affecting red blood cell production)
• An enzyme disorder affecting red blood cells (confirm with trial site)
• An abnormal hemoglobin (the protein in red blood cells that carries oxygen) that is unstable or affects how oxygen is carried in the blood
• Hereditary stomatocytosis (a rare inherited condition where red blood cells are an unusual shape)
• Hereditary pyropoikilocytosis (a rare inherited condition causing red blood cells to be very abnormally shaped)
• You have hereditary spherocytosis (a condition where red blood cells are sphere-shaped) with either very low hemoglobin levels (below 8 g/dL, meaning severe anemia) or where the diagnosis has not been clearly confirmed
• You have long-term red blood cell breakdown anemia with blood test results that point toward the condition, but standard tests (including a specific lab test called EMA binding and genetic testing) have not given a clear diagnosis
• You have not had a stem cell transplant or gene therapy at the time of joining the trial — however, if you previously had a transplant that did not work and have not had another one, you may still be eligible

Who may not be able to join:

• You are only a "carrier" of an inherited anemia condition (meaning you carry the gene but do not have the disease itself) — for example, having sickle cell trait rather than sickle cell disease

Important: Always verify eligibility with the trial site directly before applying.