Phase 3 Myasthenia Gravis Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with a severe flare-up of Myasthenia Gravis (MG), for example having difficulty swallowing, breathing problems that required a hospital stay, or weakness in the neck
• Your MG severity falls within a certain range on a standard medical scale (MGFA class II to IVb — confirm with trial site)
• You are 18 years of age or older
• Your MG symptoms (not counting eye symptoms alone) are significantly affecting your daily life, scoring 6 or above on a standard MG daily activities scale
• You have tested positive for a specific antibody linked to MG, called AChR antibody (past test results may also be acceptable)
• If you are a woman who could become pregnant, you must have a negative pregnancy test at the start of the trial
• If you could become pregnant, or if your sexual partner could become pregnant, you must be willing to use an approved form of birth control during the study and for 40 days after the last dose of the study drug
• You have received, or have started receiving, a meningococcal (meningitis) vaccine, and are following the required guidelines for antibiotic protection if needed

Who may not be able to join:

• You have a history of meningococcal disease (a type of serious bacterial infection)
• You needed a breathing tube (ventilator) before the study began
• You have had a significant recent infection, such as blood poisoning or serious wound infection, that may have caused your MG flare-up
• You are currently pregnant or breastfeeding
• You have had surgery in the last 4 weeks (minor procedures may be allowed — confirm with trial site)
• You are currently using, or have used and not responded to, a type of drug called a C5 inhibitor in the past 3 months
• You have had plasma exchange or IVIG treatment (blood-filtering or antibody treatments) in the past 4 weeks
• You are currently taking part in another clinical trial involving a treatment medication
• You have used a drug called Rituximab in the past 9 months
• You have any other significant health condition or illness that the trial doctor feels could put you at risk or affect the study results

Important: Always verify eligibility with the trial site directly before applying.