Obesity Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- Adults aged 18 or older
- People with a body mass index (BMI) of 35 or higher, measured at a pre-surgery clinic visit
- People scheduled for a planned (non-emergency) shoulder surgery on one side — such as shoulder scope, shoulder replacement, rotator cuff repair, or reverse shoulder replacement — performed under general anaesthesia at UNC Hospitals
- People whose anaesthesia plan includes a single nerve-blocking injection near the shoulder (called a brachial plexus block) to help manage pain after surgery
- People who are able to complete a breathing strength test at the screening visit, producing two consistent efforts
- People who are able to read or understand English and sign a consent form
Who may not be able to join:
- People having emergency or trauma-related shoulder surgery, or whose surgery is converted to an open (non-keyhole) procedure
- People who test positive for pregnancy on the day of surgery
- People who are currently incarcerated or who are legally unable to give their own consent
- People with severe lung disease — including advanced COPD (stage 3 or 4), certain restrictive lung conditions unrelated to weight, significant breathlessness at rest or with minimal activity, or those who use home oxygen
- People with serious heart conditions — including severe heart valve disease, advanced heart failure (Class III or IV), or blocked heart arteries causing chest pain
- People with nerve or muscle diseases that affect their breathing muscles (such as ALS or myasthenia gravis), or known paralysis of the diaphragm (the main breathing muscle)
- People with blood clotting problems (such as low platelets or an elevated clotting measure called INR), or a skin infection at the site where the nerve block would be given
- People with significant anaemia or certain inherited blood/haemoglobin conditions
- People with a known allergy to bupivacaine (a local anaesthetic), dexamethasone (a steroid), or ultrasound gel
- People using high-dose opioid pain medications (more than 100 mg oral morphine equivalent per day) in the three months before surgery
- People who have previously participated in this trial, or who are already enrolled in another interventional research study that could affect the results
- People who the investigator determines are unlikely to be able to complete the post-surgery assessments — for example, due to significant cognitive impairment or a planned transfer to another facility
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Monika Nanda, University of North Carollina at Chapel Hill
Phone: 919-966-5136
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Incidence of Early Postoperative Respiratory Compromise; Effect Modification by Preoperative Maximum Inspiratory Pressure (MIP)
Can't join this trial?
Data last synced from ClinicalTrials.gov: 21 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.