Phase 1 Bladder Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have locally advanced or metastatic cancer of one of these types: bladder cancer, squamous cell carcinoma of the lung, esophagus, skin, or an anogenital (anal or genital area) squamous cell carcinoma.
• People whose cancer has continued to grow or spread during or after standard treatment for their cancer type.
• People whose cancer can be measured on a CT scan or MRI.
• People who are generally well enough to carry out light activity and care for themselves — this is measured using a standard medical scale called ECOG, where a score of 0 or 1 is required (confirm with trial site).
• People with a life expectancy of at least 3 months.
• People whose liver, kidneys, and other organs are functioning well enough, as shown by standard blood tests.
• People who are able to provide a tumour tissue sample, either recently collected or stored from a previous biopsy.
• People who agree to use contraception during the study and for 120 days after the last dose of the study drug — this does not apply to women who have gone through menopause or have had surgery that prevents pregnancy.

Who may not be able to join:

• People whose cancer may be treatable with a targeted therapy that is known to be beneficial for their tumour type.
• People who still have significant ongoing side effects from previous cancer treatments.
• People who have cancer that has spread to the brain, unless that spread was previously treated and is now stable.
• People who have had a severe or life-threatening reaction to the immune system from a previous cancer treatment.
• People with a history of significant heart disease.
• People with severe oesophageal (food pipe) conditions, such as a rupture or severe inflammation of the oesophagus.
• People with active inflammation, erosion, or ulcers affecting the eyes (cornea or conjunctiva).
• People with a history of cirrhosis (serious liver scarring) or significantly raised pressure in the liver's blood vessels.
• People with an uncontrolled or serious active infection.
• People who have been diagnosed with certain other cancers within the past 3 years (confirm with trial site for which cancers apply).
• People who have had a blood clot in an artery, stroke, or mini-stroke (TIA) within the past 6 months.
• People with active or uncontrolled HIV, hepatitis B, or hepatitis C infection.
• People with an autoimmune condition or any other condition that requires ongoing medication to suppress the immune system.

Important: Always verify eligibility with the trial site directly before applying.