Phase 3 Oesophageal Cancer Trial, Recruiting NCT07221149 Sponsor: Bristol-Myers Squibb Condition: Oesophageal Cancer
Back to Oesophageal Cancer

Phase 3 Oesophageal Cancer Trial, Recruiting

NCT07221149
Recruiting Phase 3 🇦🇺 Australian site

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • People who have advanced or metastatic stomach cancer, cancer at the junction between the stomach and oesophagus, or cancer in the lower oesophagus, confirmed through a tissue or cell sample, and who have not yet received any systemic (whole-body) treatment for their advanced or metastatic disease.
  • People who have had a test result recorded for a protein called PD-L1, which is found on some cancer cells (for one phase of the trial, any PD-L1 result is accepted; for another phase, a result of 1 or higher is required).
  • People whose cancer has tested negative for a protein called HER2, based on local laboratory guidelines.
  • People whose cancer can be measured using standard imaging guidelines (known as RECIST v1.1).

Who may not be able to join:

  • People who have cancer that has spread to the brain or spinal cord and has not yet been treated.
  • People who have had a serious heart-related event — such as a heart attack, unstable chest pain, stroke, or blood clot in an artery — within the 6 months before joining, or who have blood pressure that remains very high despite treatment, or who have a specific inherited heart rhythm condition called congenital long QT syndrome.
  • People who have a known major blood-clotting disorder, such as haemophilia.
  • People who have had a blood clot in a deep vein or in the lungs within the 3 months before joining, unless the clot has been fully treated and/or the person has been on a stable dose of blood-thinning medication (confirm with trial site).
  • People who have had a hole or abnormal opening in the stomach or intestines within 6 months before joining.
  • People who have had major surgery, a surgical biopsy, or a serious injury within 28 days before joining, or for whom major surgery is expected to be needed during the trial.
  • Additional criteria set out in the trial protocol may also apply (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 27 July 2026
Phase 3: approximately ~65% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Principal Investigator: Bristol-Myers Squibb, Bristol-Myers Squibb

Phone: 855-907-3286

Australian sites

Local Institution - 0176, Liverpool, New South Wales
Sunshine Coast University Hospital, Birtinya, Queensland
+61752021111
Lyell McEwin Hospital, Elizabeth Vale, South Australia
0881829000
Monash Health, Clayton, Victoria
(03)95946666
Warringal Medical Centre, Melbourne, Victoria
0410582006
St. John of God Murdoch Hospital, Murdoch, Western Australia
+61894389599

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 3
Registry
ClinicalTrials.gov
Start date
13 March 2026
Est. completion
8 November 2030

Where this trial is recruiting

🇦🇷 Argentina 🇦🇺 Australia 🇧🇷 Brazil 🇨🇦 Canada 🇨🇱 Chile 🇨🇳 China 🇨🇴 Colombia 🇫🇷 France 🇩🇪 Germany 🇮🇳 India 🇮🇹 Italy 🇯🇵 Japan 🇲🇽 Mexico 🇵🇱 Poland 🇷🇴 Romania 🇰🇷 South Korea 🇪🇸 Spain Turkey (Türkiye) 🇬🇧 United Kingdom 🇺🇸 United States

6 site(s) in Australia. Confirm current status and contact details directly with the trial site.

Primary endpoints

Objective Response (OR) (confirmed complete response (CR) or partial response (PR)) by Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 per investigator assessment; Progression Free Survival (PFS) by RECIST v1.1 per blinded independent central review (BICR); Overall survival (OS)

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 27 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov