Migraine Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged between 18 and 80 years old.
• People who have been diagnosed with chronic migraine affecting both sides of the head, with their first migraine occurring before age 50, based on recognised international headache diagnostic standards.
• People whose chronic migraines have not been adequately controlled by, or who could not tolerate, at least 2 different categories of migraine prevention medications (such as beta-blockers, anti-seizure medications, anti-depressants, CGRP antibody treatments, or Botox injections), and whose chronic migraines have continued for at least 12 months before joining, including at least 6 months after those 2 medication categories were tried.
• People who have not used opioids (such as codeine or morphine) or barbiturates specifically to treat their migraines (use of these medications for other medical reasons is acceptable).
• People who have had a brain MRI/MRA scan within the past 3 years as part of their routine care, which did not find any other underlying cause for their headaches.
• People who had at least one day in the past month completely free of migraines, as recorded in a headache diary.
• People with a MIDAS score of 21 or higher, which reflects severely disabling migraines (confirm with trial site if unsure how to calculate this score).
• People who are able to read and write in English, as the study assessments have only been validated in English.
• People who are able to sign their own informed consent form.
• People who are able to complete all study visits and requirements as outlined in the study plan.

Who may not be able to join:

• People who have previously had brain or neck vascular surgery or procedures, including brain surgery, shunt placement, certain brain monitoring procedures, or carotid artery surgery.
• People who have used opioids or barbiturates to treat chronic migraine at any point in the past year.
• People who currently have a lesion or abnormality in the brain identified on a routine care MRI scan.
• People who have previously had radiation treatment to the head.
• People who have been diagnosed with certain other headache types in addition to chronic migraine, such as hemiplegic migraine, basilar migraine, new daily persistent headache, or cluster headache.
• People with significant liver disease or a creatinine blood level above 2.0 mg/dL indicating reduced kidney function (people with elevated creatinine who are on dialysis may still be considered eligible — confirm with trial site).
• People with a history of cancer or immune system disorders such as multiple sclerosis, rheumatoid arthritis, or other autoimmune diseases.
• People with a history of a life-threatening allergic reaction to radiographic contrast dye (people with this allergy may still be considered eligible if the allergy can be managed medically — confirm with trial site).
• People who are currently enrolled in another migraine study or receiving any experimental migraine treatment.
• People with additional medical or personal circumstances that the principal investigator determines could interfere with the study results or the person's ability to safely complete the study.
• People who were previously diagnosed with chronic migraine but whose migraines have since become less frequent due to successful treatment, meaning they now experience episodic rather than chronic migraine.

Important: Always verify eligibility with the trial site directly before applying.