Phase 3 Chronic Kidney Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older, of any gender
• People who have been diagnosed with chronic kidney disease (CKD)
• People whose kidneys are working at a reduced but not severely low level, based on a specific kidney function test result (eGFR between 25 and 60)
• People whose urine shows a certain level of protein leakage and whose blood potassium level falls within a specific range (confirm with trial site for exact values)
• People whose blood pressure, measured while sitting in a clinic, falls within a specific elevated range (systolic reading between 130 and 170 mmHg)
• People who have been taking a water tablet (furosemide or a similar medication) at a certain dose, along with a specific heart and kidney medication called finerenone at 10 mg daily, for at least 30 days
• People who are willing and able to follow all parts of the study plan and sign a consent form (or have a legally recognised representative do so)
• People who are willing to use reliable contraception during sexual activity with a partner of the opposite sex for the duration of the study

Who may not be able to join:

• People who have been diagnosed with Type 1 diabetes
• People with uncontrolled high blood pressure (systolic reading above 170 mmHg)
• People with a condition called primary aldosteronism or other hormonal disorders affecting similar body systems
• People whose blood potassium level falls outside a specific narrow range at the time of screening
• People who are unable to continue taking finerenone at 10 mg daily, or who need a higher dose of their water tablet than the study allows
• People who have had an acute (sudden) kidney injury within the past 3 months
• People who have had a serious heart or blood vessel event — such as a heart attack, stroke, mini-stroke, or blood clot in the lungs — within the past 3 months, or a certain type of heart procedure within the past month
• People who were admitted to hospital for worsening heart failure in the past 30 days
• People with an inherited form of polycystic kidney disease (either type)
• People with a condition called Addison's disease (a disorder of the adrenal glands)
• People with a certain level of liver disease (classified using the Child-Pugh system — confirm with trial site)
• People with kidney disease caused by lupus, a condition called ANCA-associated vasculitis, or any other kidney disease that requires immune-suppressing medications
• People who have had an organ transplant at any time
• People who need to take a type of water tablet known as potassium-sparing diuretics
• People who currently have an active cancer
• People who are currently taking potassium supplements or potassium binders
• People who have a known allergy or sensitivity to sulfonamide-based medicines, spironolactone, or finerenone
• People who are pregnant, breastfeeding, or planning to become pregnant during the study
• People who have taken part in another clinical trial involving an experimental drug within the past 30 days
• People whom the trial investigator considers unsuitable for any other reason that could affect their safety or the reliability of the study results

Important: Always verify eligibility with the trial site directly before applying.