Phase 1 Sickle Cell Disease Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You have been diagnosed with sickle cell disease (any type)
- You are already enrolled in a program at the institution called SCCRIP (Sickle Cell Clinical Research Intervention Program)
- You are between 8 and 17 years old (up to your 18th birthday)
- In the past 2 years, you scored at or below the 16th percentile on at least 2 out of 4 specific thinking and attention tests (confirm with trial site which tests apply to you)
- OR in the past 2 years, a parent rated your attention or thinking skills at or above the 84th percentile on one of two specific behaviour rating questionnaires, suggesting noticeable difficulties (confirm with trial site)
- OR you have been formally diagnosed with ADHD (any type) in the past 2 years
- English is your main language at home
- Both the child and at least one parent are willing to take part and sign the required consent forms
- If applicable, a negative pregnancy test is required before joining
Who may not be able to join:
- English is not your primary language
- You scored very low (below the 2nd percentile) on a standard IQ test called the WASI-2
- You have had a seizure within the past 6 months that is not well controlled
- You have a heart muscle disease (cardiomyopathy) or a heart defect you were born with
- You have certain heart valve problems, a narrowing of a specific heart artery, or a history of heart muscle or heart lining inflammation
- You have a history of certain abnormal heart rhythms, or take medicines known to affect heart rhythm (confirm with trial site)
- You have had two or more episodes of a painful, long-lasting erection (called priapism)
- Your blood pressure has been higher than the normal range for your age at your three most recent hospital visits in a row
- You have taken stimulant medication (such as ADHD medication) within the past two weeks
- You have severe hearing or vision loss
- You have had a bad reaction to a medicine called methylphenidate in the past
- You or your parent/guardian are unwilling or unable to sign the consent forms
- You are currently taking part in another clinical trial involving an experimental medicine
- You are currently taking any of the following medicines: phenobarbital, phenytoin, primidone (seizure medicines), warfarin (a blood thinner), antipsychotic medicines, SSRI antidepressants, tricyclic antidepressants, or vasopressor medicines (medicines used to raise blood pressure)
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Andrew W. Heitzer, PhD, St. Jude Children's Research Hospital
Phone: 888-226-4343
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Assess feasibility of methylphenidate; Assess acceptability of methylphenidate; Assess adherence to methylphenidate
Can't join this trial?
Data last synced from ClinicalTrials.gov: 26 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.