Phase 2 Obesity Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who were diagnosed with acute lymphoblastic leukemia (a type of blood cancer) and treated with chemotherapy only, at least 5 years ago
• People who finished their cancer treatment at least 2 years ago
• People who test negative for pregnancy at the start of the trial (if female)
• People who are 18 years of age or older at the time of joining
• People who have obesity (a body mass index, or BMI, above 30) or who are overweight (BMI above 27) and also have at least one weight-related health condition, such as high blood pressure, abnormal cholesterol or blood fat levels, obstructive sleep apnea (interrupted breathing during sleep), or certain heart conditions

Who may not be able to join:

• People who have been diagnosed with diabetes, or whose blood test results at the start of the trial suggest they may have diabetes
• People who have used weight loss medications in the past 3 months, or who have lost more than 5kg in the past 3 months (a list of specific medications applies — confirm with trial site)
• People who are taking metformin or any other medication to lower blood sugar, including for conditions like polycystic ovary syndrome
• People who have a condition called Multiple Endocrine Neoplasia Type 2, or a family history of a specific type of thyroid cancer called medullary thyroid cancer
• People with severely reduced kidney function
• People who have had a major heart or stroke-related event in the past 3 months, such as a heart attack, stroke, or unstable chest pain, or who currently have severe heart failure symptoms
• People with very high blood pressure that is not under control at their clinic visit
• People with known active or chronic liver disease, or abnormal liver blood test results above a certain level
• People with known chronic inflammation of the pancreas, or who have had an episode of acute pancreatitis in the past year
• People who are currently pregnant, within 3 months of giving birth, breastfeeding, or planning to become pregnant during the trial
• People who have significant problems with how their stomach empties food, or who regularly take medications that affect how the digestive system moves food
• People who have received an organ transplant or are waiting for one
• People who currently have active cancer or are receiving treatment for cancer
• People with an underactive thyroid that is not being treated and has certain abnormal blood test results, or who have symptoms related to an underactive thyroid
• People with a serious mental health condition such as major depression, schizophrenia, bipolar disorder, or significant anxiety, or who have a history of a suicide attempt
• People who score 15 or higher on a standard depression screening questionnaire at the start of the trial
• People with a known history of drug or alcohol use disorder that, in the opinion of the trial doctor, may prevent them from completing the trial
• People who have used marijuana in the past 3 months and are unwilling to stop during the trial
• People who are unable to give themselves injections of the study drug and do not have a trained support person available to help them
• People whose cognitive (thinking or memory) difficulties, in the opinion of the trial doctor, would prevent them from safely taking part in the trial
• People who do not speak English
• People who do not have access to WiFi, which is needed for exercise sessions in the trial
• People who live in a location where the trial medication cannot be shipped, based on current pharmacy restrictions at the organising institution (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.