Phase 1 Leukaemia Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older (any gender)
• You have been diagnosed with a blood cancer that has come back or stopped responding to treatment, specifically B-cell acute lymphoblastic leukaemia (B-ALL), B-cell lymphoma, or multiple myeloma
• You are generally able to carry out daily activities with little to no limitation, and are expected to live for at least 3 more months (confirm with trial site)
• Your blood test results meet certain minimum levels for red blood cells, white blood cells, platelets, and lymphocytes during the screening period (confirm with trial site)
• Your kidneys are working well enough, based on a blood test taken during screening (confirm with trial site)
• Your liver function results are within acceptable ranges during screening (confirm with trial site)
• Your heart is pumping well enough, with no significant fluid around the heart or abnormal heart rhythm readings, based on tests done during screening (confirm with trial site)
• Your blood oxygen level is at least 90% during screening
• If you are a woman who could become pregnant, you must have a negative pregnancy test at screening and not be breastfeeding
• You and your partner (if applicable) must agree to use effective birth control and not donate eggs or sperm from the time you sign the consent form until 1 year after finishing the study treatment
• You, or your legal representative, are willing and able to sign a consent form agreeing to take part in the study

Who may not be able to join:

• You have received chemotherapy, targeted therapy, or immunotherapy recently (within a specific number of days before starting the trial), or radiotherapy within 4 weeks before starting (confirm with trial site for exact timeframes)
• You have had a stem cell transplant (either from a donor or using your own cells) within the 3 months before starting the trial
• You have a history of another type of cancer, unless it was fully treated with no signs of disease for at least 2 years, or it was a type of skin cancer (not melanoma) that has been fully treated with no current signs
• You have previously received a treatment involving a specific type of engineered virus called a VSVG pseudotyped virus (confirm with trial site)
• You have a serious, uncontrolled infection (such as bacterial, viral, or fungal) during the screening period
• You have significant heart problems, such as serious heart failure, a recent heart attack, a recent heart bypass or stent procedure (within 6 months), significant irregular heartbeat, unexplained fainting, or a history of serious heart muscle disease
• You have certain other serious medical conditions, including a primary immune system disorder, a stroke or seizure within the past 6 months, clear signs of dementia or significant mental status changes, or Parkinson's disease or a similar movement disorder
• You have had surgery within 2 weeks before starting the trial, or have surgery planned within 2 weeks after starting (minor procedures done under local anaesthetic may be exempt — confirm with trial site)
• You have received a live vaccine within 1 month before starting the trial
• You have had a severe allergic reaction to this treatment or its ingredients in the past
• A vein cannot be found or accessed easily enough for an intravenous drip
• The trial doctor believes there is another reason why joining the trial would not be suitable for you

Important: Always verify eligibility with the trial site directly before applying.