Phase 2 Stomach Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are 18 years of age or older at the time of signing the consent form
• People who are expected to live for at least 3 months
• People who have an advanced solid tumour (one that cannot be removed by surgery and/or has spread to other parts of the body), confirmed by laboratory testing of tissue or cells — with additional tumour tissue requirements depending on which part of the trial a person is entering (confirm with trial site)
• In Part 1A: People whose cancer has already been treated with at least one standard treatment that either stopped working or caused intolerable side effects, and who have no other suitable treatment options according to their doctor — preference is given to people whose cancer has a specific genetic feature (MSI-H or dMMR) that progressed after immunotherapy, or whose cancer does not have that feature but has progressed after certain chemotherapy types
• People who have measurable areas of disease that can be tracked using standard imaging criteria (RECIST 1.1), as determined by the treating doctor
• People with a physical performance score of 0 or 1 on a standard scale (meaning largely or fully able to carry out normal daily activities) (confirm with trial site)
• People whose heart, liver, kidneys, and blood counts are functioning adequately (confirm with trial site)

Who may not be able to join:

• People who have not yet recovered from side effects of previous cancer treatments (side effects must have returned to mild or baseline levels)
• People who have previously been treated with a WRN inhibitor (a specific type of experimental drug)
• People with a known or suspected serious allergy or hypersensitivity to the study drug or its ingredients, including anyone who has had a serious allergic reaction requiring hospitalisation
• In Parts 1B and Part 2 Rescue: people who have an immune system condition, or who have been taking steroid medications above a certain dose (more than 10 mg of prednisone or equivalent per day) or other immune-suppressing medications within 7 days before starting the study drug
• People who have another active or recently treated cancer (other than the one being studied) within the past 3 years
• People with active cancer that has spread to the brain or the lining of the brain — though people with previously treated and stable brain metastases who have not needed steroids for at least 14 days may be considered (confirm with trial site)
• People whose heart's electrical activity shows a certain abnormality on three separate ECG readings (a QTcF measurement above 470 ms)
• People with an active autoimmune disease that has needed systemic treatment in the past 2 years — though some conditions such as Type 1 diabetes, thyroid conditions managed with hormone replacement, or certain skin conditions not requiring systemic treatment may still be eligible (confirm with trial site)
• People with a history of serious lung inflammation (pneumonitis or interstitial lung disease) that required steroid treatment, or who currently have these conditions
• People with active tuberculosis
• People with any active infection currently requiring treatment with systemic medications

Important: Always verify eligibility with the trial site directly before applying.