Phase 2 Lung Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are willing to sign a consent form and follow the study rules
• You are between 18 and 75 years old
• You have no gender restrictions — anyone may apply
• Your doctors expect you to live for at least 3 more months
• You have been diagnosed with locally advanced or metastatic non-squamous non-small cell lung cancer (a specific type of lung cancer that has spread)
• Your cancer has been confirmed to have high levels of a protein called HER2
• You are able to provide a stored tumor tissue sample from the past 2 years
• You have at least one area of cancer that can be measured on a scan
• You are generally able to carry out daily activities with little or no restriction (confirm with trial site)
• Any side effects from previous cancer treatments have mostly gone away
• Your heart is pumping well, with no serious heart problems
• Your organs (such as kidneys and liver) are functioning at an acceptable level (confirm with trial site)
• If you are a woman who could become pregnant, you must have a negative pregnancy test within 7 days before starting the trial and not be breastfeeding; all participants must use effective contraception during treatment and for 7 months after it ends

Who may not be able to join:

• You had surgery, intensive radiotherapy, immunotherapy, or similar treatments within the past 4 weeks (or within a certain time based on the treatment used)
• Your cancer pathology shows it also contains small cell carcinoma or sarcomatoid carcinoma components (specific cancer subtypes)
• You have previously been treated with HER2-targeted therapies or a specific type of antibody-drug treatment (confirm with trial site)
• You had a serious heart or stroke-related event in the past 6 months
• You have another lung disease that is severely affecting your breathing
• You have certain heart rhythm or electrical problems, such as a prolonged QT interval or serious heart block (confirm with trial site)
• You have been diagnosed with another type of cancer within the past 5 years
• You have high blood pressure that is not well controlled
• You have a history of a type of lung inflammation (non-infectious ILD) that required steroid treatment, or you currently have lung inflammation
• You have cancer that has spread to the brain, the lining of the brain, or the spinal cord
• You have had allergic reactions to certain antibody-based medicines, or to the specific drugs used in this trial
• You needed steroid or immune-suppressing medicines within the past 2 weeks
• You have large, symptomatic, or poorly controlled fluid build-up around your organs (such as around the lungs or heart)
• You developed a new deep vein blood clot (DVT) within the past 14 days (unless you have a venous filter in place)
• You had a serious body-wide infection within the past 4 weeks
• You have an active autoimmune or inflammatory disease
• You are HIV positive, or have active hepatitis B or hepatitis C infection
• You have had a bone marrow, stem cell, or organ transplant in the past
• You have a serious neurological or psychiatric condition
• You have other significant health problems or abnormal test results that the trial doctor believes would make participation unsafe or unsuitable

Important: Always verify eligibility with the trial site directly before applying.