Phase 1 Head and Neck Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are willing to sign a consent form and follow the study requirements
• People of any gender
• People aged 18 to 75 years (for the Phase Ia part of the study) or aged 18 and older (for the Phase Ib part)
• People with a life expectancy of at least 3 months
• People who have a solid tumour that has spread locally or to other parts of the body, confirmed by a tissue or cell test, and whose cancer has not responded to standard treatments
• People who can provide a stored or fresh tumour tissue sample from within the past 3 years
• People who have at least one tumour that can be measured using standard imaging guidelines (confirm with trial site)
• People who are generally well enough to carry out daily activities, based on a standard physical fitness score of 0 or 1 (confirm with trial site)
• People whose side effects from previous cancer treatments have mostly resolved to a mild level
• People with healthy heart function, with the heart pumping at least 50% of its capacity
• People whose liver, kidney, and other organ functions meet the required levels (confirm with trial site for specific values)
• People with normal blood clotting results within accepted ranges (confirm with trial site for specific values)
• People with low or no protein detected in their urine
• Women who could become pregnant must have a negative pregnancy test within 7 days before starting the study, must not be breastfeeding, and all participants regardless of gender must use effective barrier contraception during the study and for 6 months after it ends

Who may not be able to join:

• People who have had chemotherapy, biological therapy, or immunotherapy within the 4 weeks (or 5 half-lives of the drug) before starting the trial
• People with a history of serious heart disease
• People with certain heart rhythm abnormalities, including prolonged QT interval, complete left bundle branch block, or third-degree heart block (confirm with trial site)
• People with currently active autoimmune or inflammatory conditions
• People diagnosed with another cancer within the past 5 years
• People with high blood pressure that remains poorly controlled even while taking two blood pressure medications
• People with a history of a lung condition called interstitial lung disease that required steroid treatment, currently active interstitial lung disease, or significant radiation-related lung inflammation
• People with active symptoms from cancer that has spread to the brain or spinal cord
• People with a known allergy to certain types of antibody-based medicines or to any ingredient in the trial drug (confirm with trial site)
• People who have previously had an organ transplant or a stem cell transplant from a donor
• People who have received a high cumulative dose of a type of chemotherapy called anthracyclines in previous treatment (confirm with trial site for the specific threshold)
• People who test positive for HIV, or who have active tuberculosis, active hepatitis B, or active hepatitis C infection
• People with a current serious infection that requires treatment throughout the body, such as severe pneumonia or blood infection
• People who have taken part in another clinical trial within the 4 weeks before starting this one
• Women who are pregnant or breastfeeding
• People who the trial doctors consider unsuitable for other reasons not listed above

Important: Always verify eligibility with the trial site directly before applying.