Phase 1 Thyroid Cancer Trial, Recruiting NCT07287748 Sponsor: Alpha Fusion Inc. Condition: Thyroid Cancer
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Phase 1 Thyroid Cancer Trial, Recruiting

NCT07287748
Recruiting Phase 1

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • People who have been diagnosed with differentiated thyroid cancer (specifically papillary or follicular type) and have had their entire thyroid surgically removed
  • People whose cancer cannot be fully removed by surgery, has come back, or has spread to other parts of the body, and whose doctors have determined that standard treatments are no longer working or cannot be tolerated (this applies to one part of the trial)
  • People whose cancer cannot be fully removed by surgery, has come back, or has spread, and who have not yet received radioactive iodine treatment (this applies to another part of the trial)
  • People who have at least one tumour that can be measured on a scan
  • People whose general health is reasonably stable, rated on a standard medical scale as being fully active, restricted in strenuous activity, or capable of self-care but not active work (confirm with trial site for exact definition)
  • People who are expected to live for at least 6 more months based on their current health

Who may not be able to join:

  • People who wish to preserve their fertility
  • People who are pregnant, possibly pregnant, or breastfeeding, or people (or their partners) who are unable to agree to use appropriate contraception during the trial
  • People who currently have more than one active cancer, or who have had a separate cancer within the last 3 years
  • People who have an active infection that is not under control
  • People who test positive for hepatitis B, hepatitis C, or HIV

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 28 July 2026
Phase 1: approximately ~10% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Principal Investigator: Tahara, Chief, National Cancer Center Hospital East

Phone: +81335185330

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 1
Sponsor
Alpha Fusion Inc.
Registry
ClinicalTrials.gov
Start date
1 January 2026
Est. completion
31 July 2028

Where this trial is recruiting

🇯🇵 Japan

Primary endpoints

Ph1a: DLT (Dose-limiting toxicity ) based on Japanese translation of the Common Terminology Criteria for Adverse Events (CTCAE) version 5.0, Japan Clinical Oncology Group (JCOG) version; Ph1b: Assessment of tumor reduction effect on MRI or CT scan images

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov