Phase 2 Long COVID Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with Post COVID (Long COVID) according to World Health Organization criteria, confirmed by a doctor who specialises in Post COVID conditions
• People who experience post-exertional malaise (a worsening of symptoms after physical or mental effort), as measured by a specific questionnaire called the DSQ-PEM
• People whose disability level falls within a moderate range on a scale called Bell's Disability Score (between 20% and 70%)
• People whose initial COVID-19 illness was mild and did not require hospitalisation
• People who had no limitations in daily activities or physical functioning before their initial COVID-19 infection, as measured by a WHO performance scale

Who may not be able to join:

• People who are at risk of heart rhythm or electrical conduction problems
• People who have had significant bowel or stomach surgery, or have a condition that affects how the gut moves food through, in a way that could affect how the study medication is absorbed
• People with a significant active heart or lung condition
• People with an unstable neurological (brain or nerve) condition
• People with a significant active mental health condition that currently requires treatment
• People with a history of substance misuse or addiction
• People who have had an active cancer diagnosis within the past 5 years
• People who have had an organ transplant (such as a kidney, liver, or heart)
• People with an active HIV, hepatitis B, or hepatitis C infection
• People whose body mass index (a height-to-weight measure) is below 18.5 or above 35
• People who are pregnant or breastfeeding
• People whose routine blood or laboratory test results fall outside the normal reference range in a clinically significant way
• People taking certain vitamins and supplements — including multivitamins, co-enzyme Q10, Vitamin E, riboflavin, amino acids, or antioxidant supplements — unless the dose has been stable for at least one month before the study and stays stable throughout (confirm with trial site)
• People taking certain medications that can affect how the study drug is processed by the body, including specific antifungals, some HIV medications, some epilepsy medications, rifampicin, St. John's Wort, and several others (confirm with trial site for the full list)
• People taking medications known to affect heart rhythm, unless their heart's electrical activity has been confirmed as normal during a stable period of treatment (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.