Phase 4 Migraine Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have had episodic migraine (with or without aura) for at least 1 year, diagnosed according to standard international headache guidelines
• Adults aged 18 or older
• People who have had an average of 2 to 8 moderate or severe migraine attacks per month over the last 3 months before the screening visit
• People whose migraines first started before the age of 50
• People whose migraine attacks typically last between 4 and 72 hours without treatment
• People who have at least 48 hours between migraine attacks
• People who are able to tell the difference between their migraines and other headache types, such as tension headaches or cluster headaches
• People already on a standard migraine treatment who have been on a stable, unchanged dose for at least 3 months before joining, and who are willing to keep that regimen unchanged during the study
• People who have previously been treated with Botox or certain migraine-specific antibody treatments (mAbs) within the last 6 months (confirm with trial site)
• People who, during a lead-in period before the trial, experience migraines at least 75% of the time after being exposed to a known trigger — acceptable triggers include exercise, alcohol within low limits (less than one drink per day for women, less than two per day for men), air travel of no more than 12 hours, sexual activity, fasting of no more than 24 hours, stress, or weekend/let-down

Who may not be able to join:

• People currently using certain migraine medications called gepants — specifically atogepant (taken daily), rimegepant (taken every other day), zavegepant, or ubrogepant
• People who have regularly used opioid painkillers (such as morphine, codeine, oxycodone, or hydrocodone) or medications containing barbiturates on 5 or more days per month for 3 or more months before screening
• People with a current diagnosis of uncontrolled, unstable, or recently diagnosed heart or cardiovascular disease, uncontrolled high blood pressure, or uncontrolled diabetes
• People currently diagnosed with major depression requiring treatment with atypical antipsychotic medications, schizophrenia, bipolar disorder, or borderline personality disorder
• Women who are currently pregnant, breastfeeding, or lactating

Important: Always verify eligibility with the trial site directly before applying.