Phase 3 Head and Neck Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged between 18 and 70 years old
• People who have been diagnosed with nasopharyngeal carcinoma (a type of cancer in the back of the nose and throat), confirmed by laboratory testing, classified as WHO type I, II, or III
• People whose cancer is at a stage that has not spread to distant parts of the body (Stage I–III under international staging guidelines)
• People whose scans (such as a full-body PET/CT scan, or a combination of bone scan, chest CT, and abdominal ultrasound) confirm the cancer has not spread to distant organs
• People who are able to have an MRI scan
• People whose blood, liver, and kidney test results meet the minimum levels required for radiotherapy (confirm specific values with trial site)
• People who are generally well enough to carry out daily activities with no more than minor limitations, and who do not have serious heart or lung conditions that would prevent radiotherapy (assessed using standard medical scoring tools)
• People with a heart function rating of class 1 or 2 on a standard medical scale (confirm with trial site)
• People whose doctor expects them to live for at least 12 months
• People who have been fully informed about the study and have given written consent to participate

Who may not be able to join:

• People whose cancer has not been confirmed as WHO type I, II, or III nasopharyngeal carcinoma
• People whose cancer has already spread to distant parts of the body, or who have a particular pattern of spread in the lymph nodes of the neck known as "skip metastases"
• People who are pregnant (confirmed by a blood or urine test) or currently breastfeeding
• People who are unwilling to give written informed consent
• People who have previously had radiotherapy to the head or neck area
• People with other health conditions or factors that would make photon or carbon-ion radiation therapy unsafe for them
• People who would be unable to attend regular follow-up appointments due to psychological, social, family, or location-related reasons
• People with a known allergy to certain chemotherapy drugs (such as cisplatin, docetaxel, or gemcitabine) or to contrast dyes used in imaging scans during the study
• People for whom contrast-enhanced MRI is not medically safe
• People with major organ failure, or a serious uncontrolled infection or illness (such as severe heart, lung, kidney, or liver failure)
• People with a history of immune system disorders, a positive HIV test, other inherited or acquired immune deficiencies, or who have had an organ transplant or bone marrow transplant
• People who have had another type of cancer in the past, with the exception of a common, easily treated form of skin cancer (basal cell carcinoma)
• People with a history of substance or alcohol abuse
• People with any other condition, mental health concern, severely abnormal test results, or personal circumstances that the trial investigators consider likely to make safe and reliable participation difficult

Important: Always verify eligibility with the trial site directly before applying.